131I-MIBG scintigraphy in neural crest tumours. 1994

A M Samuel, and S Murugesan, and P A Kurkure, and S H Advani, and G A Sonawane, and O P Noronha
Radiation Medicine Centre, Bhabha Atomic Research Centre, Parel, Bombay.

Radioiodinated meta-iodobenzylguanidine (131I-MIBG) has been widely used for the diagnosis of neuroblastomas, pheochromocytomas, paragangliomas and medullary carcinomas of thyroid. We have developed a procedure for preparation of 131I-MIBG and studied its utility in diagnosis of primary and metastatic neural crest tumours. Studies were carried out in 54 patients. Of them 39 cases were of neuroblastomas, 1 pheochromocytoma; 6 operated medullary carcinomas; 5 paragangliomas; 2 Ewing's sarcoma and 1 Rhabdomyosarcoma; The sensitivity for the detection of primary tumours of neuroblastomas was 94% and for the detection of metastasis was 83%; while in the case of paragangliomas and medullary carcinoma, the sensitivity was 75% and 70% respectively. Our experience in the present study shows that 131I-MIBG scintigraphy is a sensitive and specific diagnostic tool to localise primary and metastatic disease of neural crest tumours.

UI MeSH Term Description Entries
D007457 Iodine Radioisotopes Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes. Radioisotopes, Iodine
D007462 Iodobenzenes Any derivative of BENZENE that contains IODINE.
D009432 Neural Crest The two longitudinal ridges along the PRIMITIVE STREAK appearing near the end of GASTRULATION during development of nervous system (NEURULATION). The ridges are formed by folding of NEURAL PLATE. Between the ridges is a neural groove which deepens as the fold become elevated. When the folds meet at midline, the groove becomes a closed tube, the NEURAL TUBE. Neural Crest Cells,Neural Fold,Neural Groove,Cell, Neural Crest,Cells, Neural Crest,Crest, Neural,Crests, Neural,Fold, Neural,Folds, Neural,Groove, Neural,Grooves, Neural,Neural Crest Cell,Neural Crests,Neural Folds,Neural Grooves
D009447 Neuroblastoma A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51) Neuroblastomas
D011877 Radionuclide Imaging The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph. Gamma Camera Imaging,Radioisotope Scanning,Scanning, Radioisotope,Scintigraphy,Scintiphotography,Imaging, Gamma Camera,Imaging, Radionuclide
D001859 Bone Neoplasms Tumors or cancer located in bone tissue or specific BONES. Bone Cancer,Cancer of Bone,Cancer of the Bone,Neoplasms, Bone,Bone Neoplasm,Neoplasm, Bone
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000310 Adrenal Gland Neoplasms Tumors or cancer of the ADRENAL GLANDS. Adrenal Cancer,Adrenal Gland Cancer,Adrenal Neoplasm,Cancer of the Adrenal Gland,Neoplasms, Adrenal Gland,Adrenal Cancers,Adrenal Gland Cancers,Adrenal Gland Neoplasm,Adrenal Neoplasms,Cancer, Adrenal,Cancer, Adrenal Gland,Cancers, Adrenal,Cancers, Adrenal Gland,Neoplasm, Adrenal,Neoplasm, Adrenal Gland,Neoplasms, Adrenal
D012680 Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed) Specificity,Sensitivity,Specificity and Sensitivity

Related Publications

A M Samuel, and S Murugesan, and P A Kurkure, and S H Advani, and G A Sonawane, and O P Noronha
January 1997, Anticancer research,
A M Samuel, and S Murugesan, and P A Kurkure, and S H Advani, and G A Sonawane, and O P Noronha
September 1992, The British journal of radiology,
A M Samuel, and S Murugesan, and P A Kurkure, and S H Advani, and G A Sonawane, and O P Noronha
November 1994, Kaku igaku. The Japanese journal of nuclear medicine,
A M Samuel, and S Murugesan, and P A Kurkure, and S H Advani, and G A Sonawane, and O P Noronha
April 1988, Rinsho hoshasen. Clinical radiography,
A M Samuel, and S Murugesan, and P A Kurkure, and S H Advani, and G A Sonawane, and O P Noronha
July 1987, Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association,
A M Samuel, and S Murugesan, and P A Kurkure, and S H Advani, and G A Sonawane, and O P Noronha
March 2013, The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...,
A M Samuel, and S Murugesan, and P A Kurkure, and S H Advani, and G A Sonawane, and O P Noronha
March 1993, Kaku igaku. The Japanese journal of nuclear medicine,
A M Samuel, and S Murugesan, and P A Kurkure, and S H Advani, and G A Sonawane, and O P Noronha
February 1990, Hinyokika kiyo. Acta urologica Japonica,
A M Samuel, and S Murugesan, and P A Kurkure, and S H Advani, and G A Sonawane, and O P Noronha
February 1986, Kaku igaku. The Japanese journal of nuclear medicine,
A M Samuel, and S Murugesan, and P A Kurkure, and S H Advani, and G A Sonawane, and O P Noronha
July 1985, Surgery,
Copied contents to your clipboard!