-transparent.png){kind=logo}
Construction and characterization of attenuated delta aroA delta virG Shigella flexneri 2a strain CVD 1203, a prototype live oral vaccine. 1994
Department of Pediatrics, University of Maryland School of Medicine, Baltimore 21201.
We engineered an oral Shigella vaccine prototype that can invade intestinal epithelial cells but cannot undergo extensive intracellular replication or extend to adjacent epithelial cells. Strain CVD 1203, derived from wild-type Shigella flexneri 2a by introducing deletions in chromosomal aroA and invasion plasmid virG, was highly attenuated in the Sereny test. Two 10(9)-CFU orogastric doses (2 weeks apart) stimulated production of secretory immunoglobulin A antibodies to S. flexneri 2a and protected against conjunctival sac challenge with virulent S. flexneri 2a.
Related Publications
F R Noriega, and
J Y Wang, and
G Losonsky, and
D R Maneval, and
D M Hone, and
M M Levine
October 2005,
Wei sheng wu xue bao = Acta microbiologica Sinica,
F R Noriega, and
J Y Wang, and
G Losonsky, and
D R Maneval, and
D M Hone, and
M M Levine
November 1996,
Infection and immunity,
F R Noriega, and
J Y Wang, and
G Losonsky, and
D R Maneval, and
D M Hone, and
M M Levine
January 1995,
Vaccine,
F R Noriega, and
J Y Wang, and
G Losonsky, and
D R Maneval, and
D M Hone, and
M M Levine
March 2007,
Vaccine,
F R Noriega, and
J Y Wang, and
G Losonsky, and
D R Maneval, and
D M Hone, and
M M Levine
April 2002,
Infection and immunity,
F R Noriega, and
J Y Wang, and
G Losonsky, and
D R Maneval, and
D M Hone, and
M M Levine
March 2000,
Infection and immunity,
F R Noriega, and
J Y Wang, and
G Losonsky, and
D R Maneval, and
D M Hone, and
M M Levine
May 2001,
Infection and immunity,
F R Noriega, and
J Y Wang, and
G Losonsky, and
D R Maneval, and
D M Hone, and
M M Levine
July 2016,
Pathogens and disease,
F R Noriega, and
J Y Wang, and
G Losonsky, and
D R Maneval, and
D M Hone, and
M M Levine
April 2000,
Vaccine,
F R Noriega, and
J Y Wang, and
G Losonsky, and
D R Maneval, and
D M Hone, and
M M Levine
March 2018,
Journal of translational medicine,
