BIOMAT Database Logo BIOMAT Database Logo

Strains of Mycobacterium tuberculosis differ in susceptibility to reactive nitrogen intermediates in vitro. 1994

L O'Brien, and J Carmichael, and D B Lowrie, and P W Andrew
Department of Microbiology and Immunology, University of Leicester, United Kingdom.

The effects on the viability of Mycobacterium tuberculosis strains and one Mycobacterium bovis strain from exposure to sodium nitrite for 24 h, in both neutral and acidic media, were tested. The in vitro resistance of mycobacteria to reactive nitrogen intermediates, generated at an acidic pH, was found to have a significant (P < 0.05) positive correlation to the virulence of strains in guinea pigs.

UI MeSH Term Description Entries
D009163 Mycobacterium bovis The bovine variety of the tubercle bacillus. It is called also Mycobacterium tuberculosis var. bovis. BCG,Calmette-Guerin Bacillus
D009169 Mycobacterium tuberculosis A species of gram-positive, aerobic bacteria that produces TUBERCULOSIS in humans, other primates, CATTLE; DOGS; and some other animals which have contact with humans. Growth tends to be in serpentine, cordlike masses in which the bacilli show a parallel orientation. Mycobacterium tuberculosis H37Rv
D009569 Nitric Oxide A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP. Endogenous Nitrate Vasodilator,Mononitrogen Monoxide,Nitric Oxide, Endothelium-Derived,Nitrogen Monoxide,Endothelium-Derived Nitric Oxide,Monoxide, Mononitrogen,Monoxide, Nitrogen,Nitrate Vasodilator, Endogenous,Nitric Oxide, Endothelium Derived,Oxide, Nitric,Vasodilator, Endogenous Nitrate
D009573 Nitrites Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M Nitrite
D006863 Hydrogen-Ion Concentration The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH pH,Concentration, Hydrogen-Ion,Concentrations, Hydrogen-Ion,Hydrogen Ion Concentration,Hydrogen-Ion Concentrations
D066298 In Vitro Techniques Methods to study reactions or processes taking place in an artificial environment outside the living organism. In Vitro Test,In Vitro Testing,In Vitro Tests,In Vitro as Topic,In Vitro,In Vitro Technique,In Vitro Testings,Technique, In Vitro,Techniques, In Vitro,Test, In Vitro,Testing, In Vitro,Testings, In Vitro,Tests, In Vitro,Vitro Testing, In

Related Publications

L O'Brien, and J Carmichael, and D B Lowrie, and P W Andrew
Susceptibility of a panel of virulent strains of Mycobacterium tuberculosis to reactive nitrogen intermediates.
April 1997, Infection and immunity,
L O'Brien, and J Carmichael, and D B Lowrie, and P W Andrew
Mycobacterium tuberculosis CDC1551 is resistant to reactive nitrogen and oxygen intermediates in vitro.
July 2002, Infection and immunity,
L O'Brien, and J Carmichael, and D B Lowrie, and P W Andrew
Reactive nitrogen intermediates have a bacteriostatic effect on Mycobacterium tuberculosis in vitro.
September 2002, Journal of clinical microbiology,
L O'Brien, and J Carmichael, and D B Lowrie, and P W Andrew
Response of Mycobacterium tuberculosis to reactive oxygen and nitrogen intermediates.
January 1996, Molecular medicine (Cambridge, Mass.),
L O'Brien, and J Carmichael, and D B Lowrie, and P W Andrew
Reduced susceptibility of clinical strains of Mycobacterium tuberculosis to reactive nitrogen species promotes survival in activated macrophages.
January 2017, PloS one,
L O'Brien, and J Carmichael, and D B Lowrie, and P W Andrew
In vitro susceptibility testing of Mycobacterium tuberculosis strains to trifluoperazine.
June 1999, Journal of chemotherapy (Florence, Italy),
L O'Brien, and J Carmichael, and D B Lowrie, and P W Andrew
The effects of reactive nitrogen intermediates on gene expression in Mycobacterium tuberculosis.
September 2003, Cellular microbiology,
L O'Brien, and J Carmichael, and D B Lowrie, and P W Andrew
Surfactant protein A suppresses reactive nitrogen intermediates by alveolar macrophages in response to Mycobacterium tuberculosis.
February 1999, The Journal of clinical investigation,
L O'Brien, and J Carmichael, and D B Lowrie, and P W Andrew
Reactive nitrogen and oxygen intermediates and bacterial defenses: unusual adaptations in Mycobacterium tuberculosis.
February 2002, Antioxidants & redox signaling,
L O'Brien, and J Carmichael, and D B Lowrie, and P W Andrew
Reactive nitrogen intermediate susceptibility of Mycobacterium tuberculosis genotypes in an urban setting.
May 2009, The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease,
Copied contents to your clipboard!