BIOMAT Database Logo BIOMAT Database Logo

Naturally occurring hepatitis B virus mutants with deletions in the core promoter region. 1994

T Laskus, and J Rakela, and M J Tong, and M J Nowicki, and J W Mosley, and D H Persing
Mayo Clinic, Rochester, MN 55905.

A novel class of hepatitis B virus mutants in patients with chronic hepatitis B is described. The predicted effect of the mutations is to disrupt the X open reading frame. The location of the genetic alterations within the putative precore promoter also suggests that they may ameliorate precore transcription, which would provide an alternate mechanism for HBeAg(-) escape variation. Definitive conclusions regarding the effects of these mutations must await additional in vitro and in vivo studies.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D008969 Molecular Sequence Data Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. Sequence Data, Molecular,Molecular Sequencing Data,Data, Molecular Sequence,Data, Molecular Sequencing,Sequencing Data, Molecular
D009154 Mutation Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. Mutations
D011401 Promoter Regions, Genetic DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes. rRNA Promoter,Early Promoters, Genetic,Late Promoters, Genetic,Middle Promoters, Genetic,Promoter Regions,Promoter, Genetic,Promotor Regions,Promotor, Genetic,Pseudopromoter, Genetic,Early Promoter, Genetic,Genetic Late Promoter,Genetic Middle Promoters,Genetic Promoter,Genetic Promoter Region,Genetic Promoter Regions,Genetic Promoters,Genetic Promotor,Genetic Promotors,Genetic Pseudopromoter,Genetic Pseudopromoters,Late Promoter, Genetic,Middle Promoter, Genetic,Promoter Region,Promoter Region, Genetic,Promoter, Genetic Early,Promoter, rRNA,Promoters, Genetic,Promoters, Genetic Middle,Promoters, rRNA,Promotor Region,Promotors, Genetic,Pseudopromoters, Genetic,Region, Genetic Promoter,Region, Promoter,Region, Promotor,Regions, Genetic Promoter,Regions, Promoter,Regions, Promotor,rRNA Promoters
D002872 Chromosome Deletion Actual loss of portion of a chromosome. Monosomy, Partial,Partial Monosomy,Deletion, Chromosome,Deletions, Chromosome,Monosomies, Partial,Partial Monosomies
D005260 Female Females
D005784 Gene Amplification A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication. Amplification, Gene
D006509 Hepatitis B INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact. Hepatitis B Virus Infection
D006515 Hepatitis B virus The type species of the genus ORTHOHEPADNAVIRUS which causes human HEPATITIS B and is also apparently a causal agent in human HEPATOCELLULAR CARCINOMA. The Dane particle is an intact hepatitis virion, named after its discoverer. Non-infectious spherical and tubular particles are also seen in the serum. Dane Particle,Hepatitis Virus, Homologous Serum,B virus, Hepatitis,Hepatitis B viruses,Particle, Dane,viruses, Hepatitis B

Related Publications

T Laskus, and J Rakela, and M J Tong, and M J Nowicki, and J W Mosley, and D H Persing
Genome replication, virion secretion, and e antigen expression of naturally occurring hepatitis B virus core promoter mutants.
June 2003, Journal of virology,
T Laskus, and J Rakela, and M J Tong, and M J Nowicki, and J W Mosley, and D H Persing
Hepatitis B virus: significance of naturally occurring mutants.
January 1993, Intervirology,
T Laskus, and J Rakela, and M J Tong, and M J Nowicki, and J W Mosley, and D H Persing
Naturally occurring hepatitis B virus core gene mutations.
July 1995, Hepatology (Baltimore, Md.),
T Laskus, and J Rakela, and M J Tong, and M J Nowicki, and J W Mosley, and D H Persing
Naturally occurring mutations define a novel function of the hepatitis B virus core promoter in core protein expression.
August 1998, Journal of virology,
T Laskus, and J Rakela, and M J Tong, and M J Nowicki, and J W Mosley, and D H Persing
Naturally occurring deletions/insertions in HBV core promoter tend to decrease in hepatitis B e antigen-positive chronic hepatitis B patients during antiviral therapy.
January 2015, Antiviral therapy,
T Laskus, and J Rakela, and M J Tong, and M J Nowicki, and J W Mosley, and D H Persing
Virion Secretion of Hepatitis B Virus Naturally Occurring Core Antigen Variants.
December 2020, Cells,
T Laskus, and J Rakela, and M J Tong, and M J Nowicki, and J W Mosley, and D H Persing
Naturally occurring hepatitis B virus X deletions and insertions among Korean chronic patients.
January 2011, Journal of medical virology,
T Laskus, and J Rakela, and M J Tong, and M J Nowicki, and J W Mosley, and D H Persing
Naturally occurring hepatitis B virus B-cell and T-cell epitope mutants in hepatitis B vaccinated children.
January 2013, TheScientificWorldJournal,
T Laskus, and J Rakela, and M J Tong, and M J Nowicki, and J W Mosley, and D H Persing
Naturally occurring precore/core region mutations of hepatitis B virus genotype C related to hepatocellular carcinoma.
January 2012, PloS one,
T Laskus, and J Rakela, and M J Tong, and M J Nowicki, and J W Mosley, and D H Persing
Mutations in the core promoter region of hepatitis B virus in patients with chronic hepatitis B.
June 1996, Journal of medical virology,
Copied contents to your clipboard!