BIOMAT Database Logo BIOMAT Database Logo

Free recirculation of memory B cells versus antigen-dependent differentiation to antibody-forming cells. 1994

M F Bachmann, and T M Kündig, and B Odermatt, and H Hengartner, and R M Zinkernagel
Department of Pathology, University of Zürich, Switzerland.

This study investigated whether or not the localization of persisting Ag influenced the localization of memory B and/or of Ab-forming cells (AFC). As a model Ag, we used vesicular stomatitis virus, which does not measurably replicate extraneuronally in adult mice after peripheral infection. Our results show that memory B cells and AFC are induced at the site where Ag is present; induced memory B cells then recirculate throughout the lymphoid system independently of Ag localization. In contrast, AFC are induced only at the sites of Ag persistence. These triggered Ab producing cells do not recirculate through the lymphoid tissue but migrate to the bone marrow.

UI MeSH Term Description Entries
D007156 Immunologic Memory The altered state of immunologic responsiveness resulting from initial contact with antigen, which enables the individual to produce antibodies more rapidly and in greater quantity in response to secondary antigenic stimulus. Immune Memory,Immunological Memory,Memory, Immunologic,Immune Memories,Immunologic Memories,Immunological Memories,Memory, Immune,Memory, Immunological
D008198 Lymph Nodes They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system. Lymph Node,Node, Lymph,Nodes, Lymph
D008221 Lymphoid Tissue Specialized tissues that are components of the lymphatic system. They provide fixed locations within the body where a variety of LYMPHOCYTES can form, mature and multiply. The lymphoid tissues are connected by a network of LYMPHATIC VESSELS. Lymphatic Tissue,Lymphatic Tissues,Lymphoid Tissues,Tissue, Lymphatic,Tissue, Lymphoid,Tissues, Lymphatic,Tissues, Lymphoid
D008811 Mice, Inbred DBA An inbred strain of mouse. Specific substrains are used in a variety of areas of BIOMEDICAL RESEARCH such as DBA/1J, which is used as a model for RHEUMATOID ARTHRITIS. Mice, DBA,Mouse, DBA,Mouse, Inbred DBA,DBA Mice,DBA Mice, Inbred,DBA Mouse,DBA Mouse, Inbred,Inbred DBA Mice,Inbred DBA Mouse
D001854 Bone Marrow Cells Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells. Bone Marrow Cell,Cell, Bone Marrow,Cells, Bone Marrow,Marrow Cell, Bone,Marrow Cells, Bone
D002454 Cell Differentiation Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs. Differentiation, Cell,Cell Differentiations,Differentiations, Cell
D002465 Cell Movement The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell. Cell Migration,Locomotion, Cell,Migration, Cell,Motility, Cell,Movement, Cell,Cell Locomotion,Cell Motility,Cell Movements,Movements, Cell
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000921 Antibody-Producing Cells Cells of the lymphoid series that can react with antigen to produce specific cell products called antibodies. Various cell subpopulations, often B-lymphocytes, can be defined, based on the different classes of immunoglobulins that they synthesize. Antibody-Producing Cell,Antibody-Secreting Cell,Antibody-Secreting Cells,Immunoglobulin-Producing Cells,Immunoglobulin-Secreting Cells,Antibody Producing Cell,Antibody Producing Cells,Antibody Secreting Cell,Antibody Secreting Cells,Cell, Antibody-Producing,Cell, Antibody-Secreting,Cell, Immunoglobulin-Producing,Cell, Immunoglobulin-Secreting,Cells, Antibody-Producing,Cells, Antibody-Secreting,Cells, Immunoglobulin-Producing,Cells, Immunoglobulin-Secreting,Immunoglobulin Producing Cells,Immunoglobulin Secreting Cells,Immunoglobulin-Producing Cell,Immunoglobulin-Secreting Cell
D000956 Antigens, Viral Substances elaborated by viruses that have antigenic activity. Viral Antigen,Viral Antigens,Antigen, Viral

Related Publications

M F Bachmann, and T M Kündig, and B Odermatt, and H Hengartner, and R M Zinkernagel
Differentiation of antigenic markers on B cells and on antibody-forming cells.
December 1975, Israel journal of medical sciences,
M F Bachmann, and T M Kündig, and B Odermatt, and H Hengartner, and R M Zinkernagel
Protective long-term antibody memory by antigen-driven and T help-dependent differentiation of long-lived memory B cells to short-lived plasma cells independent of secondary lymphoid organs.
November 2000, Proceedings of the National Academy of Sciences of the United States of America,
M F Bachmann, and T M Kündig, and B Odermatt, and H Hengartner, and R M Zinkernagel
Differentiation of antibody-forming cells. II. Effect of antigen dose on proliferation of precursor cells and plaque-forming cells.
April 1969, Journal of immunology (Baltimore, Md. : 1950),
M F Bachmann, and T M Kündig, and B Odermatt, and H Hengartner, and R M Zinkernagel
Differentiation of antibody-forming cells. I. Ratio of precursor cells to antibody-forming cells in the mouse spleen.
January 1968, Journal of immunology (Baltimore, Md. : 1950),
M F Bachmann, and T M Kündig, and B Odermatt, and H Hengartner, and R M Zinkernagel
Transcriptional profiling of antigen-dependent murine B cell differentiation and memory formation.
November 2007, Journal of immunology (Baltimore, Md. : 1950),
M F Bachmann, and T M Kündig, and B Odermatt, and H Hengartner, and R M Zinkernagel
High-affinity IgM+ memory B cells are defective in differentiation into IgM antibody-secreting cells by re-stimulation with a T cell-dependent antigen.
September 2018, Scientific reports,
M F Bachmann, and T M Kündig, and B Odermatt, and H Hengartner, and R M Zinkernagel
Generation of memory cells. III. Antibody class requirements for the generation of B-memory cells by antigen--antibody complexes.
June 1979, Immunology,
M F Bachmann, and T M Kündig, and B Odermatt, and H Hengartner, and R M Zinkernagel
The generation of memory cells. II. Generation of B memory cells with preformed antigen-antibody complexes.
April 1978, Immunology,
M F Bachmann, and T M Kündig, and B Odermatt, and H Hengartner, and R M Zinkernagel
Functional heterogeneity of marginal zone B cells revealed by their ability to generate both early antibody-forming cells and germinal centers with hypermutation and memory in response to a T-dependent antigen.
December 2003, The Journal of experimental medicine,
M F Bachmann, and T M Kündig, and B Odermatt, and H Hengartner, and R M Zinkernagel
Antigen-dependent regulation of IgE antibody production by human antigen-specific B cells.
December 1996, Journal of immunology (Baltimore, Md. : 1950),
Copied contents to your clipboard!