-transparent.png){kind=logo}
Although precocious puberty is common in boys with human chorionic gonadotropin (hCG)-secreting brain tumors, it is extremely rare in girls. The authors describe a 6-year-old girl with an hCG-secreting suprasellar immature teratoma who presented with diabetes insipidus, increased intracranial pressure, and precocious puberty. On admission, breast budding was observed. The serum hCG level was 1230 mIU/ml. Both luteinizing hormone (LH) and follicle-stimulating hormone (FSH) remained below detectable levels, even after gonadotropin-releasing hormone stimulation. Serum estrogen and androgen were moderately elevated. After chemotherapy, breast budding disappeared with normalization of serum hCG. It has been believed that hCG does not produce precocious puberty in girls in the absence of FSH, and this has been used as an explanation for the rarity of precocious puberty in girls with hCG-secreting brain tumors. However, it has also been reported that hCG has not only LH activity but also intrinsic, although weak, FSH-like activity. In the present case, this FSH-like activity was considered to have played a role in the development of precocious puberty. It is speculated that a very high level of serum hCG can produce precocious puberty in girls. The rarity of intracranial germ-cell tumors with a high potential of hCG secretion may be one of the reasons why hCG-induced precocious puberty is uncommon in girls.
C Kitanaka, and
M Matsutani, and
S Sora, and
S Kitanaka, and
A Tanae, and
I Hibi
December 2021,
Endocrine journal,
C Kitanaka, and
M Matsutani, and
S Sora, and
S Kitanaka, and
A Tanae, and
I Hibi
March 1974,
No shinkei geka. Neurological surgery,
C Kitanaka, and
M Matsutani, and
S Sora, and
S Kitanaka, and
A Tanae, and
I Hibi
June 2001,
Journal of pediatric endocrinology & metabolism : JPEM,
C Kitanaka, and
M Matsutani, and
S Sora, and
S Kitanaka, and
A Tanae, and
I Hibi
January 2002,
Journal of pediatric endocrinology & metabolism : JPEM,
C Kitanaka, and
M Matsutani, and
S Sora, and
S Kitanaka, and
A Tanae, and
I Hibi
April 1991,
Neurosurgery,
C Kitanaka, and
M Matsutani, and
S Sora, and
S Kitanaka, and
A Tanae, and
I Hibi
December 2018,
Archivos argentinos de pediatria,
C Kitanaka, and
M Matsutani, and
S Sora, and
S Kitanaka, and
A Tanae, and
I Hibi
May 1980,
Helvetica paediatrica acta,
C Kitanaka, and
M Matsutani, and
S Sora, and
S Kitanaka, and
A Tanae, and
I Hibi
April 1977,
No shinkei geka. Neurological surgery,
C Kitanaka, and
M Matsutani, and
S Sora, and
S Kitanaka, and
A Tanae, and
I Hibi
March 1980,
Annales de pediatrie,
C Kitanaka, and
M Matsutani, and
S Sora, and
S Kitanaka, and
A Tanae, and
I Hibi
January 1981,
La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris,
