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Since macrocytosis was observed in a high percentage of our renal transplant patients, a follow-up study was carried out on 36 patients with determination of the mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and haemoglobin concentration (MCHC). These parameters were determined monthly for periods of up to two years (16 cases) following transplantation. There was a rise in both MCV and MCH within one month. Macrooperative MCHC, however, remained normal. Anaemia was absent or mild. The bone marrow showed striking megaloblastic changes with nuclear-cytoplasmatic dissociation in both red and white cell precursors. Vitamin B 12 absorption tests were normal in all 8 patients investigated. Macrocytosis was not detectable in two patients with a low serum iron concentration. Macrocytosis disappeared in 4 patients with chronic rejection when progressive renal failure developed. It is concluded that azathioprine therapy induces macrocytosis in renal transplant patients provided renal function is satisfactory.
P Schmidt, and
H Kopsa, and
P Pils, and
J Zazgornik, and
E Deutsch
November 1979,
Medicina clinica,
P Schmidt, and
H Kopsa, and
P Pils, and
J Zazgornik, and
E Deutsch
January 1980,
Acta medica Austriaca,
P Schmidt, and
H Kopsa, and
P Pils, and
J Zazgornik, and
E Deutsch
June 1975,
Archives francaises des maladies de l'appareil digestif,
P Schmidt, and
H Kopsa, and
P Pils, and
J Zazgornik, and
E Deutsch
January 1975,
Przeglad lekarski,
P Schmidt, and
H Kopsa, and
P Pils, and
J Zazgornik, and
E Deutsch
March 1997,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
P Schmidt, and
H Kopsa, and
P Pils, and
J Zazgornik, and
E Deutsch
October 1981,
Medicina clinica,
P Schmidt, and
H Kopsa, and
P Pils, and
J Zazgornik, and
E Deutsch
January 1977,
Gastroenterologie clinique et biologique,
P Schmidt, and
H Kopsa, and
P Pils, and
J Zazgornik, and
E Deutsch
January 1978,
Der Urologe. Ausg. A,
P Schmidt, and
H Kopsa, and
P Pils, and
J Zazgornik, and
E Deutsch
January 1980,
Klinische Wochenschrift,
P Schmidt, and
H Kopsa, and
P Pils, and
J Zazgornik, and
E Deutsch
December 1978,
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology,
