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We evaluated the use of sonography in monitoring the efficacy of suppressive therapy with a gonadotropin releasing hormone analogue in girls being treated for isosexual precocious puberty. Ten girls 5 to 9 years of age underwent serial sonography and hormonal stimulation tests on the same day. Sonographic trends of decreasing ovarian volume and uterine length indicated early suppression even when absolute values were above threshold. Changes in ovarian volume were the most sensitive predictor of pituitary-gonadal suppression. Sonography is a sensitive and accurate method of monitoring medical therapy; ovarian volume and analysis of interval change are the most sensitive barometers of change.
M M Ambrosino, and
M Hernanz-Schulman, and
N B Genieser, and
C A Sklar, and
N R Fefferman, and
R David
November 1985,
Acta paediatrica Scandinavica,
M M Ambrosino, and
M Hernanz-Schulman, and
N B Genieser, and
C A Sklar, and
N R Fefferman, and
R David
January 1987,
Pediatrician,
M M Ambrosino, and
M Hernanz-Schulman, and
N B Genieser, and
C A Sklar, and
N R Fefferman, and
R David
December 1985,
American journal of diseases of children (1960),
M M Ambrosino, and
M Hernanz-Schulman, and
N B Genieser, and
C A Sklar, and
N R Fefferman, and
R David
July 1966,
Ceskoslovenska pediatrie,
M M Ambrosino, and
M Hernanz-Schulman, and
N B Genieser, and
C A Sklar, and
N R Fefferman, and
R David
October 1964,
American journal of diseases of children (1960),
M M Ambrosino, and
M Hernanz-Schulman, and
N B Genieser, and
C A Sklar, and
N R Fefferman, and
R David
July 1984,
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine,
M M Ambrosino, and
M Hernanz-Schulman, and
N B Genieser, and
C A Sklar, and
N R Fefferman, and
R David
August 1982,
New York state journal of medicine,
M M Ambrosino, and
M Hernanz-Schulman, and
N B Genieser, and
C A Sklar, and
N R Fefferman, and
R David
March 1982,
Lancet (London, England),
M M Ambrosino, and
M Hernanz-Schulman, and
N B Genieser, and
C A Sklar, and
N R Fefferman, and
R David
June 1974,
Radiology,
M M Ambrosino, and
M Hernanz-Schulman, and
N B Genieser, and
C A Sklar, and
N R Fefferman, and
R David
December 2002,
Pediatrics,
