Biomaterial Database

A comparative double-blind study of the side effects of Litarex and Lithionit Durettes. 1976

E Widerlöv

Side effects of two lithium salts of the sustained-release type were compared in a cross-over double-blind study. Eighteen patients with uni- or bipolar type of manic-depressive diseases were included in the trial. The drugs compared were lithium citrate (Litarex, Dumex Ltd.) and lithium sulphate (Lithionit Durettes, Hässle Ltd.). After the patients had been adjusted to a serum concentration of 0.8-1.2 mmol/l, self-assessment of the frequency and intensity of 16 side-effect variables was performed during a period of 4 weeks. The most common side effects were tremor, fatigue, polyuria, polydipsia, and reduced power of concentration. There was no difference in the frequency or intensity of the side effects between the two drugs. The side effects are, accordingly, considered an effect of the lithium ion, rather than of the lithium salt. The difference in the size and appearance of the tablets was of very little practical significance.

UI	MeSH Term	Description	Entries
D008094	Lithium	An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of lithium are used in treating BIPOLAR DISORDER.	Lithium-7,Lithium 7
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D011141	Polyuria	Urination of a large volume of urine with an increase in urinary frequency, commonly seen in diabetes (DIABETES MELLITUS; DIABETES INSIPIDUS).	Polyurias
D002951	Citrates	Derivatives of CITRIC ACID.
D002986	Clinical Trials as Topic	Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.	Clinical Trial as Topic
D004341	Drug Evaluation	Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.	Evaluation Studies, Drug,Drug Evaluation Studies,Drug Evaluation Study,Drug Evaluations,Evaluation Study, Drug,Evaluation, Drug,Evaluations, Drug,Studies, Drug Evaluation,Study, Drug Evaluation
D005221	Fatigue	The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.	Lassitude
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man