-transparent.png){kind=logo}
The effects of intravenous diltiazem (0.5 and 1.0 mg.kg-1) on muscle compound action potential (CAP) elicited from gastrocnemius muscle by sciatic nerve stimulation in cats were investigated. Analysis was performed on the amplitude of CAP, recovery curve (RC) and train-of-four ratio (TOFR). There was no response in any parameter after administering 0.5 mg.kg-1. On the other hand, diltiazem 1.0 mg.kg-1 produced significant depression only in the amplitude of CAP, but no change was observed in both RC and TOFR. It is concluded that approximately ten times the therapeutic dose of diltiazem is necessary to modify the neuromuscular transmission.
Related Publications
T Suzuki, and
H Shiraishi, and
N Katsumata, and
H Saitoh, and
K Tai, and
S Ogawa, and
H Suzuki
January 1990,
The Japanese journal of physiology,
T Suzuki, and
H Shiraishi, and
N Katsumata, and
H Saitoh, and
K Tai, and
S Ogawa, and
H Suzuki
September 1993,
Brain research,
T Suzuki, and
H Shiraishi, and
N Katsumata, and
H Saitoh, and
K Tai, and
S Ogawa, and
H Suzuki
December 1976,
Anesthesiology,
T Suzuki, and
H Shiraishi, and
N Katsumata, and
H Saitoh, and
K Tai, and
S Ogawa, and
H Suzuki
January 1995,
In vivo (Athens, Greece),
T Suzuki, and
H Shiraishi, and
N Katsumata, and
H Saitoh, and
K Tai, and
S Ogawa, and
H Suzuki
October 1985,
European journal of pharmacology,
T Suzuki, and
H Shiraishi, and
N Katsumata, and
H Saitoh, and
K Tai, and
S Ogawa, and
H Suzuki
January 1970,
European journal of pharmacology,
T Suzuki, and
H Shiraishi, and
N Katsumata, and
H Saitoh, and
K Tai, and
S Ogawa, and
H Suzuki
June 1983,
Yao xue xue bao = Acta pharmaceutica Sinica,
T Suzuki, and
H Shiraishi, and
N Katsumata, and
H Saitoh, and
K Tai, and
S Ogawa, and
H Suzuki
June 1985,
Archives internationales de pharmacodynamie et de therapie,
T Suzuki, and
H Shiraishi, and
N Katsumata, and
H Saitoh, and
K Tai, and
S Ogawa, and
H Suzuki
May 1985,
European journal of pharmacology,
T Suzuki, and
H Shiraishi, and
N Katsumata, and
H Saitoh, and
K Tai, and
S Ogawa, and
H Suzuki
February 1983,
Circulation research,
