BIOMAT Database Logo BIOMAT Database Logo

Effect of NG-monomethyl-L-arginine on regional vascular resistance in rats. 1994

T Nakamura, and T Sakamaki, and K Sato, and Z Ono, and R L Prewitt
Second Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan.

This study investigated the effects of intravenous injection of the specific inhibitor of nitric oxide (NO) formation, NG-monomethyl-L-arginine (L-NMMA), on mean arterial pressure and regional vascular resistance in rats (n = 7). Regional vascular resistances of brain, heart, left kidney, intestine (jejunum), left testis and right testis were measured using radiolabelled microspheres before and after injection of 12.5 mg/kg of L-NMMA. Injection of L-NMMA raised mean arterial pressure significantly (p < 0.05) from 119 +/- 4 (mean +/- SEM) mmHg to 139 +/- 7 mmHg, accompanied by a significant (p < 0.05) decrease in both heart rate and cardiac index and an increase in total peripheral resistance. Regional vascular resistances in brain, heart, kidney and intestine increased significantly (p < 0.05) with L-NMMA, but no change was observed in the testes. The results indicate that the resistance of vascular beds is affected by NO synthesis, while the extent of regulation may differ among the various vascular beds.

UI MeSH Term Description Entries
D008297 Male Males
D009569 Nitric Oxide A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP. Endogenous Nitrate Vasodilator,Mononitrogen Monoxide,Nitric Oxide, Endothelium-Derived,Nitrogen Monoxide,Endothelium-Derived Nitric Oxide,Monoxide, Mononitrogen,Monoxide, Nitrogen,Nitrate Vasodilator, Endogenous,Nitric Oxide, Endothelium Derived,Oxide, Nitric,Vasodilator, Endogenous Nitrate
D006439 Hemodynamics The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM. Hemodynamic
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001120 Arginine An essential amino acid that is physiologically active in the L-form. Arginine Hydrochloride,Arginine, L-Isomer,DL-Arginine Acetate, Monohydrate,L-Arginine,Arginine, L Isomer,DL Arginine Acetate, Monohydrate,Hydrochloride, Arginine,L Arginine,L-Isomer Arginine,Monohydrate DL-Arginine Acetate
D014655 Vascular Resistance The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT. Peripheral Resistance,Total Peripheral Resistance,Pulmonary Vascular Resistance,Systemic Vascular Resistance,Peripheral Resistance, Total,Resistance, Peripheral,Resistance, Pulmonary Vascular,Resistance, Systemic Vascular,Resistance, Total Peripheral,Resistance, Vascular,Vascular Resistance, Pulmonary,Vascular Resistance, Systemic
D017208 Rats, Wistar A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain. Wistar Rat,Rat, Wistar,Wistar Rats
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D019323 omega-N-Methylarginine A competitive inhibitor of nitric oxide synthetase. D-NMMA,L-Monomethylarginine,L-NMMA,NG-Monomethyl-L-Arginine,L-NG-Monomethyl Arginine,N(G)-Methylarginine,N(G)-Monomethyl-D-Arginine,N(G)-Monomethylarginine,N(omega)-Monomethyl-L-Arginine,Arginine, L-NG-Monomethyl,L Monomethylarginine,L NG Monomethyl Arginine,NG Monomethyl L Arginine,omega N Methylarginine

Related Publications

T Nakamura, and T Sakamaki, and K Sato, and Z Ono, and R L Prewitt
The effect of NG-monomethyl-L-arginine on bladder function.
September 1996, European journal of pharmacology,
T Nakamura, and T Sakamaki, and K Sato, and Z Ono, and R L Prewitt
Pressor effect of NG-monomethyl-L-arginine in SHRSP.
December 1990, Japanese journal of pharmacology,
T Nakamura, and T Sakamaki, and K Sato, and Z Ono, and R L Prewitt
Regional haemodynamic changes during oral ingestion of NG-monomethyl-L-arginine or NG-nitro-L-arginine methyl ester in conscious Brattleboro rats.
September 1990, British journal of pharmacology,
T Nakamura, and T Sakamaki, and K Sato, and Z Ono, and R L Prewitt
Metabolism of NG-monomethyl-L-arginine.
August 1983, Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire,
T Nakamura, and T Sakamaki, and K Sato, and Z Ono, and R L Prewitt
Effect of NG-monomethyl-L-arginine on endothelium-dependent relaxation of human subcutaneous resistance arteries.
September 1990, Clinical science (London, England : 1979),
T Nakamura, and T Sakamaki, and K Sato, and Z Ono, and R L Prewitt
Endothelium independent protective effect of NG-monomethyl-L-arginine on endotoxin-induced alterations of vascular reactivity.
January 1991, Life sciences,
T Nakamura, and T Sakamaki, and K Sato, and Z Ono, and R L Prewitt
Effect of NG-monomethyl-L-arginine on the microcirculation of rat skin.
February 1997, Clinical and experimental pharmacology & physiology,
T Nakamura, and T Sakamaki, and K Sato, and Z Ono, and R L Prewitt
Effects of NG-monomethyl-L-arginine and L-arginine on acetylcholine renal response.
June 1990, Hypertension (Dallas, Tex. : 1979),
T Nakamura, and T Sakamaki, and K Sato, and Z Ono, and R L Prewitt
Effect of bradykinin antagonists, NG-monomethyl-L-arginine and L-NG-nitro arginine on phospholipase A2 induced oedema in rat paw.
January 1991, General pharmacology,
T Nakamura, and T Sakamaki, and K Sato, and Z Ono, and R L Prewitt
NG-monomethyl L-arginine is a non-specific inhibitor of vascular relaxation.
October 1989, European journal of pharmacology,
Copied contents to your clipboard!