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Amiodarone, administered orally in doses of 200 to 600 mg/day, was remarkably effective in the treatment and prevention of a wide variety of atrial and ventricular arrhythmias. Total suppression and control was provided in 98 (92.4 percent) of 106 patients with supraventricular arrhythmias and in 119 (82 percent) of 145 patients with ventricular arrhythmias. The rates of total control of the arrhythmia were: 96.6 percent in 30 patients with recurrent atrial flutter or fibrillation, 96.6 percent in 59 patients with repetitive supraventricular tachycardia, 100 percent in 27 patients with Wolff-Parkinson-White syndrome and 77.2 percent in 44 patients with recurrent ventricular tachycardia unsuccessfully treated with other drugs. Excellent results were obtained in 6 to 8 patients with repetitive ventricular tachycardia and ventricular fibrillation related to postinfarction ventricular aneurysm and in 12 of 14 patients with ventricular extrasystoles and ventricular tachycardia related to Chagasic myocarditis. Amiodarone proved safe in patients with severe congestive heart failure and severe myocardial damage. Its clinical efficacy was related to its electrophysiologic properties and to two unique properties: its wide safety margin and its cumulative effect. The latter liberates patients from a rigid hourly schedule and provides for continuous antiarrhythmic control, days and even weeks after treatment is discontinued.
M B Rosenbaum, and
P A Chiale, and
M S Halpern, and
G J Nau, and
J Przybylski, and
R J Levi, and
J O Lázzari, and
M V Elizari
October 1982,
Irish medical journal,
M B Rosenbaum, and
P A Chiale, and
M S Halpern, and
G J Nau, and
J Przybylski, and
R J Levi, and
J O Lázzari, and
M V Elizari
January 1983,
Clinical pharmacy,
M B Rosenbaum, and
P A Chiale, and
M S Halpern, and
G J Nau, and
J Przybylski, and
R J Levi, and
J O Lázzari, and
M V Elizari
October 1990,
La Revue du praticien,
M B Rosenbaum, and
P A Chiale, and
M S Halpern, and
G J Nau, and
J Przybylski, and
R J Levi, and
J O Lázzari, and
M V Elizari
April 1981,
American heart journal,
M B Rosenbaum, and
P A Chiale, and
M S Halpern, and
G J Nau, and
J Przybylski, and
R J Levi, and
J O Lázzari, and
M V Elizari
February 1990,
The American journal of cardiology,
M B Rosenbaum, and
P A Chiale, and
M S Halpern, and
G J Nau, and
J Przybylski, and
R J Levi, and
J O Lázzari, and
M V Elizari
January 1987,
Cor et vasa,
M B Rosenbaum, and
P A Chiale, and
M S Halpern, and
G J Nau, and
J Przybylski, and
R J Levi, and
J O Lázzari, and
M V Elizari
August 1996,
Nihon rinsho. Japanese journal of clinical medicine,
M B Rosenbaum, and
P A Chiale, and
M S Halpern, and
G J Nau, and
J Przybylski, and
R J Levi, and
J O Lázzari, and
M V Elizari
December 1967,
The Journal of the Florida Medical Association,
M B Rosenbaum, and
P A Chiale, and
M S Halpern, and
G J Nau, and
J Przybylski, and
R J Levi, and
J O Lázzari, and
M V Elizari
January 1966,
Kardiologiia,
M B Rosenbaum, and
P A Chiale, and
M S Halpern, and
G J Nau, and
J Przybylski, and
R J Levi, and
J O Lázzari, and
M V Elizari
November 1977,
Angiology,
