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3-5% of patients taking the 5HT1D agonist sumatriptan for migraine have chest discomfort, suggesting a cardiac origin. We have investigated an alternative explanation of an oesophageal cause in 24 volunteers after the subcutaneous administration of a supratherapeutic dose of sumatriptan (16 mg) or placebo in a randomised, double-blind crossover study. Sumatriptan did not alter the electrocardiogram but increased the amplitude (p < 0.001) and duration (p < 0.001) of oesophageal contractions without affecting velocity of propagation. Clinically abnormal motility was also increased (p = 0.001), and was more common in the 5 subjects with chest pain after sumatriptan. The effect of sumatriptan on oesophageal function provides an alternative explanation for the chest symptoms.
L A Houghton, and
J M Foster, and
P J Whorwell, and
J Morris, and
P Fowler
April 1993,
The Netherlands journal of medicine,
L A Houghton, and
J M Foster, and
P J Whorwell, and
J Morris, and
P Fowler
October 1987,
Bailliere's clinical gastroenterology,
L A Houghton, and
J M Foster, and
P J Whorwell, and
J Morris, and
P Fowler
December 1994,
Lancet (London, England),
L A Houghton, and
J M Foster, and
P J Whorwell, and
J Morris, and
P Fowler
June 1993,
Lancet (London, England),
L A Houghton, and
J M Foster, and
P J Whorwell, and
J Morris, and
P Fowler
September 1993,
Lancet (London, England),
L A Houghton, and
J M Foster, and
P J Whorwell, and
J Morris, and
P Fowler
July 1993,
Lancet (London, England),
L A Houghton, and
J M Foster, and
P J Whorwell, and
J Morris, and
P Fowler
November 1994,
Lancet (London, England),
L A Houghton, and
J M Foster, and
P J Whorwell, and
J Morris, and
P Fowler
November 1994,
Lancet (London, England),
L A Houghton, and
J M Foster, and
P J Whorwell, and
J Morris, and
P Fowler
October 1992,
Nederlands tijdschrift voor geneeskunde,
L A Houghton, and
J M Foster, and
P J Whorwell, and
J Morris, and
P Fowler
September 1992,
Nederlands tijdschrift voor geneeskunde,
