-transparent.png){kind=logo}
In critically ill patients with acute renal failure, continuous arteriovenous hemodiafiltration (CAVHD) has become an increasing popular supportive technique. An adult with acute renal failure during CAVHD therapy received fluconazole. Drug clearance by the hemodiafilter system and its total body clearance during the CAVHD period were 23-28 ml/minute and 22 ml/minute, respectively, indicating that the rate of systemic clearance was solely dependent on CAVHD in this patient. Total body clearance, area under the curve, and half-life values for this patient closely resembled those in healthy subjects. These observations suggest that patients treated with fluconazole during CAVHD should receive standard maintenance dosages, and neither supplementation nor dosage adjustment is required.
D P Nicolau, and
H Crowe, and
C H Nightingale, and
R Quintiliani
March 2015,
Critical care (London, England),
D P Nicolau, and
H Crowe, and
C H Nightingale, and
R Quintiliani
May 1990,
DICP : the annals of pharmacotherapy,
D P Nicolau, and
H Crowe, and
C H Nightingale, and
R Quintiliani
October 2003,
Intensive care medicine,
D P Nicolau, and
H Crowe, and
C H Nightingale, and
R Quintiliani
May 1992,
Critical care medicine,
D P Nicolau, and
H Crowe, and
C H Nightingale, and
R Quintiliani
April 1994,
Artificial organs,
D P Nicolau, and
H Crowe, and
C H Nightingale, and
R Quintiliani
July 1993,
Clinical pharmacokinetics,
D P Nicolau, and
H Crowe, and
C H Nightingale, and
R Quintiliani
January 1993,
Intensive care medicine,
D P Nicolau, and
H Crowe, and
C H Nightingale, and
R Quintiliani
January 1991,
Contributions to nephrology,
D P Nicolau, and
H Crowe, and
C H Nightingale, and
R Quintiliani
February 1990,
Critical care medicine,
D P Nicolau, and
H Crowe, and
C H Nightingale, and
R Quintiliani
January 1985,
Transactions - American Society for Artificial Internal Organs,
