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A suitable preparation to study the effect of dopamine (DA) on in vitro LHRH secretion is presented. Enzymatic degradation of LHRH in the incubation medium is completely inhibited by bacitracin (2 X 10(-5) M). Ahigh potassium concentration (56mM) induces an increase in LHRH release from entire pieces of mediobasal hypothalamus (MBH), but not from a synaptosomal pellet; this release is inhibited when calcium is omitted. The depolarization-induced LHRH in the MBH. In contrast, DA (10(-6)M) is not effective in vitro on MBH from ovariectomized rats but induces a fast release of LHRH from MBH of normal male and estradiol-pretreated ovariectomized rats. The preparation presented here appears to be of great interest in investigating amine-steroid-LHRH interactions at the cellular level.
W H Rotsztejn, and
J L Charli, and
E Pattou, and
J Epelbaum, and
C Kordon
August 1985,
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W H Rotsztejn, and
J L Charli, and
E Pattou, and
J Epelbaum, and
C Kordon
December 1986,
Life sciences,
W H Rotsztejn, and
J L Charli, and
E Pattou, and
J Epelbaum, and
C Kordon
April 1982,
Proceedings of the National Academy of Sciences of the United States of America,
W H Rotsztejn, and
J L Charli, and
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August 1982,
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W H Rotsztejn, and
J L Charli, and
E Pattou, and
J Epelbaum, and
C Kordon
December 1989,
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W H Rotsztejn, and
J L Charli, and
E Pattou, and
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C Kordon
November 1983,
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W H Rotsztejn, and
J L Charli, and
E Pattou, and
J Epelbaum, and
C Kordon
July 1978,
Nature,
W H Rotsztejn, and
J L Charli, and
E Pattou, and
J Epelbaum, and
C Kordon
March 1983,
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W H Rotsztejn, and
J L Charli, and
E Pattou, and
J Epelbaum, and
C Kordon
February 1976,
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W H Rotsztejn, and
J L Charli, and
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