-transparent.png){kind=logo}
The protective properties of the preparation of F. tularensis outer membranes (OM), obtained from F. tularensis vaccine strain 15, were studied in experiments on hamadryas baboons challenged subcutaneously with F. tularensis virulent strain Schu (nonarctic subspecies). The subcutaneous immunization with the OM preparation prevented the development of clinically pronounced infection in more than 70% of the monkeys challenged with F. tularensis strain Schu in a dose of 787 live microbial cells 30 days after immunization. Antibody titers determined in the immunized monkeys with the use of the agglutination test (AT) and the passive hemagglutination test (PHAT) were usual in minimal diagnostic limits (1:80 for AT and 1:320 for PHAT) and did not significantly rise by day 20 after immunization. In all intact animals infected with F. tularensis strain Schu the development of the infectious process was registered, which was accompanied by a rise in temperature exceeding 39.5 degrees C and a rise in the titer of specific antibodies.
V S Khlebnikov, and
I R Golovlev, and
V E Zhemchugov, and
A M Chugunov, and
S F Averin, and
S S Afanas'ev, and
I Ia Kalachev, and
S Iu Pchelintsev, and
N N Kislichkin
June 2010,
Journal of visualized experiments : JoVE,
V S Khlebnikov, and
I R Golovlev, and
V E Zhemchugov, and
A M Chugunov, and
S F Averin, and
S S Afanas'ev, and
I Ia Kalachev, and
S Iu Pchelintsev, and
N N Kislichkin
December 1989,
Molekuliarnaia genetika, mikrobiologiia i virusologiia,
V S Khlebnikov, and
I R Golovlev, and
V E Zhemchugov, and
A M Chugunov, and
S F Averin, and
S S Afanas'ev, and
I Ia Kalachev, and
S Iu Pchelintsev, and
N N Kislichkin
April 1992,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
V S Khlebnikov, and
I R Golovlev, and
V E Zhemchugov, and
A M Chugunov, and
S F Averin, and
S S Afanas'ev, and
I Ia Kalachev, and
S Iu Pchelintsev, and
N N Kislichkin
January 2007,
Journal of bacteriology,
V S Khlebnikov, and
I R Golovlev, and
V E Zhemchugov, and
A M Chugunov, and
S F Averin, and
S S Afanas'ev, and
I Ia Kalachev, and
S Iu Pchelintsev, and
N N Kislichkin
March 2021,
Journal of proteome research,
V S Khlebnikov, and
I R Golovlev, and
V E Zhemchugov, and
A M Chugunov, and
S F Averin, and
S S Afanas'ev, and
I Ia Kalachev, and
S Iu Pchelintsev, and
N N Kislichkin
September 1985,
Infection control : IC,
V S Khlebnikov, and
I R Golovlev, and
V E Zhemchugov, and
A M Chugunov, and
S F Averin, and
S S Afanas'ev, and
I Ia Kalachev, and
S Iu Pchelintsev, and
N N Kislichkin
January 2018,
Frontiers in cellular and infection microbiology,
V S Khlebnikov, and
I R Golovlev, and
V E Zhemchugov, and
A M Chugunov, and
S F Averin, and
S S Afanas'ev, and
I Ia Kalachev, and
S Iu Pchelintsev, and
N N Kislichkin
July 2009,
BMC microbiology,
V S Khlebnikov, and
I R Golovlev, and
V E Zhemchugov, and
A M Chugunov, and
S F Averin, and
S S Afanas'ev, and
I Ia Kalachev, and
S Iu Pchelintsev, and
N N Kislichkin
January 1982,
Voprosy virusologii,
V S Khlebnikov, and
I R Golovlev, and
V E Zhemchugov, and
A M Chugunov, and
S F Averin, and
S S Afanas'ev, and
I Ia Kalachev, and
S Iu Pchelintsev, and
N N Kislichkin
January 1990,
Nauchnye doklady vysshei shkoly. Biologicheskie nauki,
