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[Ocular histopathological studies in leprosy in the silent stage--I. Light microscopic feature]. 1994

Y Okano
Department of Ophthalmology, Okayama University Medical School, Japan.

Eyes from autopsy cases of leprosy patients (29 eyes from 16 cases) were examined histologically. In some cases immunohistochemical methods were used. In the lepromatous type, ocular complications such as keratitis and iridocyclitis were often found. In the tuberculoid type, such complications were seldom encountered. In the active stage, lepra cells and "foamy cells" showed positive reaction to acid-fast staining and anti-BCG antibody but in the silent stage they did not react. All foamy cells in both the active and the silent stage showed positive reaction to KP1, but they did not react to lysozyme or alpha 1-antitrypsin. These results suggest that the foamy cells originated from macrophages, but that their biological activity was low.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D007918 Leprosy A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the mucous membranes, and the peripheral nerves. Two polar or principal types are lepromatous and tuberculoid. Hansen's Disease,Hansen Disease
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009163 Mycobacterium bovis The bovine variety of the tubercle bacillus. It is called also Mycobacterium tuberculosis var. bovis. BCG,Calmette-Guerin Bacillus
D005128 Eye Diseases Diseases affecting the eye. Eye Disorders,Eye Disease,Eye Disorder
D005260 Female Females
D005487 Foam Cells Lipid-laden macrophages originating from monocytes or from smooth muscle cells. Cell, Foam,Cells, Foam,Foam Cell
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly

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