-transparent.png){kind=logo}
The effect of a novel ultrashort acting beta-adrenoblocker esmolol on systemic and pulmonary hemodynamics has been studied intraoperatively in 81 cardiosurgical patients. All the patients were operated under ataralgesia. Esmolol is an effective controlled agent for the treatment and prevention of supraventricular tachycardia and hyperdynamic reaction developing in cardiothoracic patients during anesthesia and surgery. Bolus injection of 100 mg esmolol exerts a negative chronotropic effect with maximum heart rate decrease by 23.3% by minute 5 and a gradual attenuation of the effect by minute 20. A parallel drop in the cardiac output by 18.5% is caused predominantly by a decrease in the heart rate and accounts for BP reduction. The above esmolol dose does not have a considerable effect on pulmonary hemodynamics and does not enhance intrapulmonary venous shunting.
A A Buniatian, and
N A Trekova, and
E V Flerov, and
I I Shitikov, and
I V Poplavskiĭ
March 1986,
Journal of clinical pharmacology,
A A Buniatian, and
N A Trekova, and
E V Flerov, and
I I Shitikov, and
I V Poplavskiĭ
August 1986,
Rational drug therapy,
A A Buniatian, and
N A Trekova, and
E V Flerov, and
I I Shitikov, and
I V Poplavskiĭ
April 1995,
International journal of clinical pharmacology and therapeutics,
A A Buniatian, and
N A Trekova, and
E V Flerov, and
I I Shitikov, and
I V Poplavskiĭ
July 2006,
Masui. The Japanese journal of anesthesiology,
A A Buniatian, and
N A Trekova, and
E V Flerov, and
I I Shitikov, and
I V Poplavskiĭ
January 1988,
Heart & lung : the journal of critical care,
A A Buniatian, and
N A Trekova, and
E V Flerov, and
I I Shitikov, and
I V Poplavskiĭ
September 2007,
Expert opinion on pharmacotherapy,
A A Buniatian, and
N A Trekova, and
E V Flerov, and
I I Shitikov, and
I V Poplavskiĭ
June 1987,
The Medical letter on drugs and therapeutics,
A A Buniatian, and
N A Trekova, and
E V Flerov, and
I I Shitikov, and
I V Poplavskiĭ
August 1984,
Journal of pharmaceutical sciences,
A A Buniatian, and
N A Trekova, and
E V Flerov, and
I I Shitikov, and
I V Poplavskiĭ
February 1988,
Chest,
A A Buniatian, and
N A Trekova, and
E V Flerov, and
I I Shitikov, and
I V Poplavskiĭ
February 1984,
International journal of clinical pharmacology, therapy, and toxicology,
