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We attempted to clarify the relationship between circulating endothelin-1 levels and bronchial hyperreactivity in asthmatic patients. Sixty-two asthmatic patients were studied for plasma endothelin-1 levels during acute asthma. The relationship between plasma endothelin-1 levels and pulmonary function (FEV1/FVC) was examined in 17 patients. Twelve patients were studied for changes in plasma endothelin-1 levels during methacholine inhalation tests. Plasma endothelin-1 levels during acute asthma correlated with the severity of acute asthma defined with the Clinical Asthma Evaluation Score, and those during the methacholine challenge test correlated with the grade of bronchoconstriction (P < .01). A significant negative correlation was observed between plasma endothelin-1 levels and FEV1/FVC ratio (P < .01). These results suggest that circulating endothelin-1 levels may reflect the severity of acute asthma.
T Aoki, and
T Kojima, and
A Ono, and
G Unishi, and
S Yoshijima, and
N Kameda-Hayashi, and
C Yamamoto, and
Y Hirata, and
Y Kobayashi
August 1994,
Polskie Archiwum Medycyny Wewnetrznej,
T Aoki, and
T Kojima, and
A Ono, and
G Unishi, and
S Yoshijima, and
N Kameda-Hayashi, and
C Yamamoto, and
Y Hirata, and
Y Kobayashi
May 1995,
American journal of respiratory and critical care medicine,
T Aoki, and
T Kojima, and
A Ono, and
G Unishi, and
S Yoshijima, and
N Kameda-Hayashi, and
C Yamamoto, and
Y Hirata, and
Y Kobayashi
October 2021,
Pathophysiology : the official journal of the International Society for Pathophysiology,
T Aoki, and
T Kojima, and
A Ono, and
G Unishi, and
S Yoshijima, and
N Kameda-Hayashi, and
C Yamamoto, and
Y Hirata, and
Y Kobayashi
November 1997,
American journal of respiratory and critical care medicine,
T Aoki, and
T Kojima, and
A Ono, and
G Unishi, and
S Yoshijima, and
N Kameda-Hayashi, and
C Yamamoto, and
Y Hirata, and
Y Kobayashi
August 1967,
Experientia,
T Aoki, and
T Kojima, and
A Ono, and
G Unishi, and
S Yoshijima, and
N Kameda-Hayashi, and
C Yamamoto, and
Y Hirata, and
Y Kobayashi
January 1997,
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association,
T Aoki, and
T Kojima, and
A Ono, and
G Unishi, and
S Yoshijima, and
N Kameda-Hayashi, and
C Yamamoto, and
Y Hirata, and
Y Kobayashi
December 1996,
Panminerva medica,
T Aoki, and
T Kojima, and
A Ono, and
G Unishi, and
S Yoshijima, and
N Kameda-Hayashi, and
C Yamamoto, and
Y Hirata, and
Y Kobayashi
September 2000,
Hypertension research : official journal of the Japanese Society of Hypertension,
T Aoki, and
T Kojima, and
A Ono, and
G Unishi, and
S Yoshijima, and
N Kameda-Hayashi, and
C Yamamoto, and
Y Hirata, and
Y Kobayashi
August 2003,
Respiratory medicine,
T Aoki, and
T Kojima, and
A Ono, and
G Unishi, and
S Yoshijima, and
N Kameda-Hayashi, and
C Yamamoto, and
Y Hirata, and
Y Kobayashi
May 2000,
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology,
