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The antibody repertoire is very large with at least 10(9) different antibody specificities, yet there are currently only 800 variable-region sequences known and < 23 Fab structures deposited with the Brookhaven Protein Data Bank. To engineer the antibody-combining site rationally, we need to define the rules that govern antibody structure. To understand the process of antibody-antigen recognition, we need not only to predict complementary determining regions accurately, but to simulate accurately the interaction of antibody with antigen. We have made progress in the modeling of antibody-combining sites and in the simulation of antibody complex formation. The combination of these approaches will allow us to extend the natural limits of antibody-combining sites in a more rational manner.
D M Webster, and
J Pedersen, and
D Staunton, and
A Jones, and
A R Rees
January 1991,
Methods in enzymology,
D M Webster, and
J Pedersen, and
D Staunton, and
A Jones, and
A R Rees
January 1976,
Annales d'immunologie,
D M Webster, and
J Pedersen, and
D Staunton, and
A Jones, and
A R Rees
January 1995,
Methods in molecular biology (Clifton, N.J.),
D M Webster, and
J Pedersen, and
D Staunton, and
A Jones, and
A R Rees
January 1991,
Methods in enzymology,
D M Webster, and
J Pedersen, and
D Staunton, and
A Jones, and
A R Rees
January 1990,
Biochemical Society symposium,
D M Webster, and
J Pedersen, and
D Staunton, and
A Jones, and
A R Rees
January 1991,
Ciba Foundation symposium,
D M Webster, and
J Pedersen, and
D Staunton, and
A Jones, and
A R Rees
April 1995,
Therapeutic immunology,
D M Webster, and
J Pedersen, and
D Staunton, and
A Jones, and
A R Rees
January 1993,
International reviews of immunology,
D M Webster, and
J Pedersen, and
D Staunton, and
A Jones, and
A R Rees
February 1970,
Annals of the New York Academy of Sciences,
D M Webster, and
J Pedersen, and
D Staunton, and
A Jones, and
A R Rees
January 1991,
Ciba Foundation symposium,
