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C57BL mice were injected intraperitoneally with 300,000 Cetus units/day of human recombinant interleukin-2 (rIL-2) for 2, 4, and 5 days to study its effect on salivary gland function and morphology. The pilocarpine-stimulated parotid salivary flow was collected via cannulation of the glandular duct. Total salivary protein was assayed spectrophotometrically, salivary electrolytes were determined by atomic absorption, and glandular lymphoid cell infiltration was evaluated histologically. After 5 days of rIL-2 administration salivary output and total salivary protein concentrations were reduced significantly. Similar changes, albeit to a lesser extent, were observed following 2 and 4 days of rIL-2 treatment. Increased lymphoid infiltration of the salivary glands was observed, and was directly related to the duration of rIL-2 administration. The effect of the lymphokine on the parotid gland gradually dwindled after cessation of treatment: 4 days posttreatment this salivary gland showed signs of recovery, which at 10 days proved to be complete. The possible use of this animal model in the study of lymphocyte-induced salivary gland diseases is discussed.
Y Marmary, and
E Okon, and
J Katz, and
E Shiloni
August 1987,
Immunology letters,
Y Marmary, and
E Okon, and
J Katz, and
E Shiloni
August 1986,
Alcoholism, clinical and experimental research,
Y Marmary, and
E Okon, and
J Katz, and
E Shiloni
October 2022,
International journal of molecular sciences,
Y Marmary, and
E Okon, and
J Katz, and
E Shiloni
June 1958,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
Y Marmary, and
E Okon, and
J Katz, and
E Shiloni
October 1987,
Deutsche zahnarztliche Zeitschrift,
Y Marmary, and
E Okon, and
J Katz, and
E Shiloni
November 1972,
Cancer,
Y Marmary, and
E Okon, and
J Katz, and
E Shiloni
January 2024,
Pflugers Archiv : European journal of physiology,
Y Marmary, and
E Okon, and
J Katz, and
E Shiloni
January 1997,
Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry,
Y Marmary, and
E Okon, and
J Katz, and
E Shiloni
January 1976,
Archives of oto-rhino-laryngology,
Y Marmary, and
E Okon, and
J Katz, and
E Shiloni
January 1963,
Acta medica Polona,
