Wavelet-type analysis of transient-evoked otoacoustic emissions. 1994

E G Pasanen, and J D Travis, and R J Thornhill
Department of Psychology, University of Texas, Austin 78712.

A transient-evoked otoacoustic emission (TEOAE) is a sound originating in the cochlea in response to a brief acoustic stimulus, such as a click. The response is typically a weak (25 dB SPL maximum) signal that lasts 20-40 ms. Analysis of TEOAEs is promising as a noninvasive technique for understanding cochlear function and as a diagnostic tool in identifying hearing loss. A TEOAE database was collected on many subjects, some of which were administered quinine to study the effect of the drug on TEOAE. Historically, FFT techniques have not worked well on TEOAE data because of the nonstationary nature of the signals. We have used a wavelet-like approach in analyzing the data by employing a set of equal-bandwidth filters, which have revealed the emission energy to be concentrated in the 800-2000 Hz range. This type of analysis is shown to be useful in examining the time progression of different frequency bands of the click-evoked emissions in subjects who took quinine.

UI MeSH Term Description Entries
D011803 Quinine An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood. Biquinate,Legatrim,Myoquin,Quinamm,Quinbisan,Quinbisul,Quindan,Quinimax,Quinine Bisulfate,Quinine Hydrochloride,Quinine Lafran,Quinine Sulfate,Quinine Sulphate,Quinine-Odan,Quinoctal,Quinson,Quinsul,Strema,Surquina,Bisulfate, Quinine,Hydrochloride, Quinine,Sulfate, Quinine,Sulphate, Quinine
D003051 Cochlea The part of the inner ear (LABYRINTH) that is concerned with hearing. It forms the anterior part of the labyrinth, as a snail-like structure that is situated almost horizontally anterior to the VESTIBULAR LABYRINTH. Cochleas
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000161 Acoustic Stimulation Use of sound to elicit a response in the nervous system. Auditory Stimulation,Stimulation, Acoustic,Stimulation, Auditory
D012815 Signal Processing, Computer-Assisted Computer-assisted processing of electric, ultrasonic, or electronic signals to interpret function and activity. Digital Signal Processing,Signal Interpretation, Computer-Assisted,Signal Processing, Digital,Computer-Assisted Signal Interpretation,Computer-Assisted Signal Interpretations,Computer-Assisted Signal Processing,Interpretation, Computer-Assisted Signal,Interpretations, Computer-Assisted Signal,Signal Interpretation, Computer Assisted,Signal Interpretations, Computer-Assisted,Signal Processing, Computer Assisted
D017084 Otoacoustic Emissions, Spontaneous Self-generated faint acoustic signals from the inner ear (COCHLEA) without external stimulation. These faint signals can be recorded in the EAR CANAL and are indications of active OUTER AUDITORY HAIR CELLS. Spontaneous otoacoustic emissions are found in all classes of land vertebrates. Spontaneous Otoacoustic Emissions,Otoacoustic Emission, Spontaneous,Spontaneous Otoacoustic Emission

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