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Hybridization studies revealed a differential accumulation of c-jun and jun B mRNA in the hippocampus and cerebral cortex of rats trained on a foot-shock-motivated brightness discrimination. Supposing that early gene expression is functionally significant for plastic changes in the brain, we used antisense phosphorothioate oligodeoxynucleotides (S-ODN) in vivo to study effects of specific inhibition of c-jun and jun B gene expression on learning and memory formation in rat brain. Discrimination performance of rats was impaired after intrahippocampal injection of anti-c-jun S-ODN but not of anti-jun B S-ODN. These results imply that topically injected antisense oligonucleotides affect processes involved in learning and memory in a sequence-specific manner.
W Tischmeyer, and
R Grimm, and
H Schicknick, and
W Brysch, and
K H Schlingensiepen
January 1999,
Learning & memory (Cold Spring Harbor, N.Y.),
W Tischmeyer, and
R Grimm, and
H Schicknick, and
W Brysch, and
K H Schlingensiepen
January 1996,
Bioconjugate chemistry,
W Tischmeyer, and
R Grimm, and
H Schicknick, and
W Brysch, and
K H Schlingensiepen
January 1993,
Antisense research and development,
W Tischmeyer, and
R Grimm, and
H Schicknick, and
W Brysch, and
K H Schlingensiepen
August 1999,
Blood,
W Tischmeyer, and
R Grimm, and
H Schicknick, and
W Brysch, and
K H Schlingensiepen
January 2007,
Oligonucleotides,
W Tischmeyer, and
R Grimm, and
H Schicknick, and
W Brysch, and
K H Schlingensiepen
October 1992,
Annals of the New York Academy of Sciences,
W Tischmeyer, and
R Grimm, and
H Schicknick, and
W Brysch, and
K H Schlingensiepen
August 1999,
Surgery,
W Tischmeyer, and
R Grimm, and
H Schicknick, and
W Brysch, and
K H Schlingensiepen
September 1997,
Anti-cancer drug design,
W Tischmeyer, and
R Grimm, and
H Schicknick, and
W Brysch, and
K H Schlingensiepen
January 2003,
Prostate cancer and prostatic diseases,
W Tischmeyer, and
R Grimm, and
H Schicknick, and
W Brysch, and
K H Schlingensiepen
January 1991,
European journal of cancer (Oxford, England : 1990),
