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Among a number of genes that escape X-chromosome inactivation in humans, three have been evaluated in mice and unexpectedly all three are subject to X-inactivation. We report here the cloning and expression studies of a novel mouse gene, Xe169, and show that it escapes X-inactivation like its human homologue. Xe169 was assigned to band F2/F3 on the mouse X chromosome by fluorescent in situ hybridization and Southern analysis indicates that the gene is located outside the pseudoautosomal region. Homologous, but divergent, sequences exist on the Y chromosome. In vitro and in vivo studies show that Xe169 is expressed from both the active and the inactive X chromosomes. Xe169 is the first cloned non-pseudoautosomal gene that escapes X-inactivation in mice.
J Wu, and
E C Salido, and
P H Yen, and
T K Mohandas, and
H H Heng, and
L C Tsui, and
J Park, and
V M Chapman, and
L J Shapiro
May 1990,
Genomics,
J Wu, and
E C Salido, and
P H Yen, and
T K Mohandas, and
H H Heng, and
L C Tsui, and
J Park, and
V M Chapman, and
L J Shapiro
January 1993,
Nature genetics,
J Wu, and
E C Salido, and
P H Yen, and
T K Mohandas, and
H H Heng, and
L C Tsui, and
J Park, and
V M Chapman, and
L J Shapiro
June 1994,
Human molecular genetics,
J Wu, and
E C Salido, and
P H Yen, and
T K Mohandas, and
H H Heng, and
L C Tsui, and
J Park, and
V M Chapman, and
L J Shapiro
July 1988,
Nucleic acids research,
J Wu, and
E C Salido, and
P H Yen, and
T K Mohandas, and
H H Heng, and
L C Tsui, and
J Park, and
V M Chapman, and
L J Shapiro
February 1995,
Human molecular genetics,
J Wu, and
E C Salido, and
P H Yen, and
T K Mohandas, and
H H Heng, and
L C Tsui, and
J Park, and
V M Chapman, and
L J Shapiro
April 1998,
Human molecular genetics,
J Wu, and
E C Salido, and
P H Yen, and
T K Mohandas, and
H H Heng, and
L C Tsui, and
J Park, and
V M Chapman, and
L J Shapiro
November 1996,
Human molecular genetics,
J Wu, and
E C Salido, and
P H Yen, and
T K Mohandas, and
H H Heng, and
L C Tsui, and
J Park, and
V M Chapman, and
L J Shapiro
April 1993,
Genomics,
J Wu, and
E C Salido, and
P H Yen, and
T K Mohandas, and
H H Heng, and
L C Tsui, and
J Park, and
V M Chapman, and
L J Shapiro
March 1996,
Somatic cell and molecular genetics,
J Wu, and
E C Salido, and
P H Yen, and
T K Mohandas, and
H H Heng, and
L C Tsui, and
J Park, and
V M Chapman, and
L J Shapiro
May 1987,
Science (New York, N.Y.),
