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In 40 patients with Alzheimer's disease (AD, < 65 years), 56 patients with senile dementia of the Alzheimer type (SDAT, > or = 65 years) and 45 patients with vascular dementia (VAD), basal cortisol levels were estimated and the dexamethasone test (DST) was performed. The degree of dementia was assessed according to DSM-III-R and the GBS scale was used for quantitative measures of functional impairment. There were no significant differences in basal cortisol levels. Especially in the VAD group, scores on functional impairment correlated significantly with post-DST cortisol levels. The results indicate hypothalamic overactivity in demented patients which can be correlated to the degree of dementia. In VAD, and to a certain extent also in SDAT, there appears to be a disconnection between cortical areas, including the hippocampus and the hypothalamus.
J Balldin, and
K Blennow, and
G Bråne, and
C G Gottfries, and
I Karlsson, and
B Regland, and
A Wallin
January 1990,
Progress in neuro-psychopharmacology & biological psychiatry,
J Balldin, and
K Blennow, and
G Bråne, and
C G Gottfries, and
I Karlsson, and
B Regland, and
A Wallin
January 1989,
Progress in clinical and biological research,
J Balldin, and
K Blennow, and
G Bråne, and
C G Gottfries, and
I Karlsson, and
B Regland, and
A Wallin
May 2010,
Journal of neural transmission (Vienna, Austria : 1996),
J Balldin, and
K Blennow, and
G Bråne, and
C G Gottfries, and
I Karlsson, and
B Regland, and
A Wallin
November 2002,
Psychopharmacology,
J Balldin, and
K Blennow, and
G Bråne, and
C G Gottfries, and
I Karlsson, and
B Regland, and
A Wallin
July 2014,
World journal of clinical cases,
J Balldin, and
K Blennow, and
G Bråne, and
C G Gottfries, and
I Karlsson, and
B Regland, and
A Wallin
May 2016,
Biological psychology,
J Balldin, and
K Blennow, and
G Bråne, and
C G Gottfries, and
I Karlsson, and
B Regland, and
A Wallin
May 2005,
The Journal of clinical endocrinology and metabolism,
J Balldin, and
K Blennow, and
G Bråne, and
C G Gottfries, and
I Karlsson, and
B Regland, and
A Wallin
September 2009,
European child & adolescent psychiatry,
J Balldin, and
K Blennow, and
G Bråne, and
C G Gottfries, and
I Karlsson, and
B Regland, and
A Wallin
December 2011,
CNS neuroscience & therapeutics,
J Balldin, and
K Blennow, and
G Bråne, and
C G Gottfries, and
I Karlsson, and
B Regland, and
A Wallin
January 2002,
Psychoneuroendocrinology,
