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Data are presented on detection of intraepithelial localization of shigellae in the biopsy materials of the large and small intestine mucosa of the patients with various forms of acute Sonne dysentery, in comparison with the clinico-morphological picture of the disease. Biopsy specimens (60 of the large and 7 of the small intestine) were stained with thionine and examined bacterioscopically; an intracellular distribution of the microbes was revealed in 58 cases; in 53 of them a subsequent identification of the microbes by the fluorescent antibody method was carried out; in 47 cases (88.7%) invasion of Sh. sonnei into the cells of the epithelium of the mucosa of the large and the small intestine was confirmed. There proved to be a direct relationship between the severity of the course of the disease, the level of shigellae localization and the extent of contamination by them of the cells of the large intestinal mucosa. The role of the penetrating capacity of shigellae in the development of the pathological process in dysentery is discussed.
M P Sinel'nikova, and
L S Logacheva, and
E A Ovchinnikova, and
I V Seppi
September 1972,
Vrachebnoe delo,
M P Sinel'nikova, and
L S Logacheva, and
E A Ovchinnikova, and
I V Seppi
December 1952,
Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete,
M P Sinel'nikova, and
L S Logacheva, and
E A Ovchinnikova, and
I V Seppi
January 1977,
Arkhiv patologii,
M P Sinel'nikova, and
L S Logacheva, and
E A Ovchinnikova, and
I V Seppi
May 1955,
Klinicheskaia meditsina,
M P Sinel'nikova, and
L S Logacheva, and
E A Ovchinnikova, and
I V Seppi
January 1974,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
M P Sinel'nikova, and
L S Logacheva, and
E A Ovchinnikova, and
I V Seppi
January 1976,
Arkhiv patologii,
M P Sinel'nikova, and
L S Logacheva, and
E A Ovchinnikova, and
I V Seppi
March 1977,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
M P Sinel'nikova, and
L S Logacheva, and
E A Ovchinnikova, and
I V Seppi
November 1975,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
M P Sinel'nikova, and
L S Logacheva, and
E A Ovchinnikova, and
I V Seppi
February 1977,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
M P Sinel'nikova, and
L S Logacheva, and
E A Ovchinnikova, and
I V Seppi
January 1976,
Trudy Leningradskogo nauchno-issledovatel'skogo instituta epidemiologii i mikrobiologii imeni Pastera,
