Biomaterial Database

[Ultrastructural observations on 24 cases of pseudo-hypertrophic muscular dystrophy]. 1994

Z B Hang, and D R Luo, and K M Wu

Department of Pathology, West China University of Medical Sciences, Chengdu, Sichuan.

Muscular biopsy specimens of 24 cases of pseudo-hypertrophic (Duchenne's) muscular dystrophy (DMD) were studied with light and electron microscopy. Ultrastructural changes include: I. Disappearance of sarcolemma in focal areas of muscle fibers with degeneration or focal necrosis, which may be the preliminary muscle fiber changes in DMD. 2. Repair of sarcolemma and regenerative sarcomere were observed in some injured muscle fibers, but the ability to repair and regeneration being so weak that injured muscle fibers can not be completely restored. 3. In the early stage of DMD when muscle fibers have not yet to become obviously atrophied, fat cell infiltration between swollen or intact muscle fibers can be observed but cannot be explained. In addition, 3 carriers (mothers of 3 DMD patients) and one asymptomatic brother of a DMD patient were examined, some serological and ultrastructural changes were found.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008854	Microscopy, Electron	Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.	Electron Microscopy
D009132	Muscles	Contractile tissue that produces movement in animals.	Muscle Tissue,Muscle,Muscle Tissues,Tissue, Muscle,Tissues, Muscle
D009136	Muscular Dystrophies	A heterogeneous group of inherited MYOPATHIES, characterized by wasting and weakness of the SKELETAL MUSCLE. They are categorized by the sites of MUSCLE WEAKNESS; AGE OF ONSET; and INHERITANCE PATTERNS.	Muscular Dystrophy,Myodystrophica,Myodystrophy,Dystrophies, Muscular,Dystrophy, Muscular,Myodystrophicas,Myodystrophies
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man