BIOMAT Database Logo BIOMAT Database Logo

Effect of vest cardiopulmonary resuscitation on cerebral and coronary perfusion in an infant porcine model. 1994

D H Shaffner, and C L Schleien, and R C Koehler, and B Eberle, and R J Traystman
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD.

OBJECTIVE To determine cerebral and myocardial blood flow rates during vest cardiopulmonary resuscitation (CPR) without direct cardiac compression in an infant porcine model. Also, to determine if circumferential chest compression without the chest deformity ordinarily associated with precordial compression maintains cerebral and myocardial blood flow rates during prolonged CPR. Finally, to establish the effect of compression rate and duty cycle on cerebral and myocardial blood flow rates during vest CPR in this model. METHODS Prospective, randomized comparison of two compression rates and two duty cycles in four groups during prolonged CPR. METHODS University cerebral resuscitation laboratory. METHODS Thirty-two infant domestic swine. METHODS Microsphere-determined cerebral and myocardial blood flow rates, perfusion pressures, and chest dimensions, were measured before and during prolonged vest CPR. Immediately after ventricular fibrillation, epinephrine administration was started and thoracic vest CPR was performed using a single combination of compression rates of 100 or 150/min and duty cycles of 30% or 60%. Measurements were made before and at 5, 10, 20, 35, and 50 mins of CPR. RESULTS Five minutes into CPR, between-group comparisons showed that cerebral blood flow was 16 to 20 mL/min/100 g and myocardial blood flow was 34 to 45 mL/min/100 g (48% to 62% and 25% to 33% of prearrest values). When CPR was prolonged, cerebral blood flow deteriorated similarly in all groups. Myocardial blood flow decreased over time but was better maintained in the groups with a 30% duty cycle (24 vs. 4 mL/min/100 g; p < .006). There were no differences between the two compression rates. Chest deformity after cessation of 50 mins of compression was < 3%. CONCLUSIONS Cerebral and myocardial blood flow rates produced by vest CPR are comparable with rates reported using other types of CPR in this model. Deterioration in blood flow during prolonged CPR occurs despite a lack of chest deformation. The deterioration in myocardial blood flow during prolonged CPR is greater when a long duty cycle is used in this model.

UI MeSH Term Description Entries
D008863 Microspheres Small uniformly-sized spherical particles, of micrometer dimensions, frequently labeled with radioisotopes or various reagents acting as tags or markers. Latex Beads,Latex Particles,Latex Spheres,Microbeads,Bead, Latex,Beads, Latex,Latex Bead,Latex Particle,Latex Sphere,Microbead,Microsphere,Particle, Latex,Particles, Latex,Sphere, Latex,Spheres, Latex
D011652 Pulmonary Circulation The circulation of the BLOOD through the LUNGS. Pulmonary Blood Flow,Respiratory Circulation,Circulation, Pulmonary,Circulation, Respiratory,Blood Flow, Pulmonary,Flow, Pulmonary Blood,Pulmonary Blood Flows
D011897 Random Allocation A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects. Randomization,Allocation, Random
D001783 Blood Flow Velocity A value equal to the total volume flow divided by the cross-sectional area of the vascular bed. Blood Flow Velocities,Flow Velocities, Blood,Flow Velocity, Blood,Velocities, Blood Flow,Velocity, Blood Flow
D002560 Cerebrovascular Circulation The circulation of blood through the BLOOD VESSELS of the BRAIN. Brain Blood Flow,Regional Cerebral Blood Flow,Cerebral Blood Flow,Cerebral Circulation,Cerebral Perfusion Pressure,Circulation, Cerebrovascular,Blood Flow, Brain,Blood Flow, Cerebral,Brain Blood Flows,Cerebral Blood Flows,Cerebral Circulations,Cerebral Perfusion Pressures,Circulation, Cerebral,Flow, Brain Blood,Flow, Cerebral Blood,Perfusion Pressure, Cerebral,Pressure, Cerebral Perfusion
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D004837 Epinephrine The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS. Adrenaline,4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol,Adrenaline Acid Tartrate,Adrenaline Bitartrate,Adrenaline Hydrochloride,Epifrin,Epinephrine Acetate,Epinephrine Bitartrate,Epinephrine Hydrochloride,Epinephrine Hydrogen Tartrate,Epitrate,Lyophrin,Medihaler-Epi,Acetate, Epinephrine
D000704 Analysis of Variance A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable. ANOVA,Analysis, Variance,Variance Analysis,Analyses, Variance,Variance Analyses
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013552 Swine Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA). Phacochoerus,Pigs,Suidae,Warthogs,Wart Hogs,Hog, Wart,Hogs, Wart,Wart Hog

Related Publications

D H Shaffner, and C L Schleien, and R C Koehler, and B Eberle, and R J Traystman
The effect of resuscitation position on cerebral and coronary perfusion pressure during mechanical cardiopulmonary resuscitation in porcine cardiac arrest model.
April 2017, Resuscitation,
D H Shaffner, and C L Schleien, and R C Koehler, and B Eberle, and R J Traystman
Effect of epinephrine on cerebral and myocardial perfusion in an infant animal preparation of cardiopulmonary resuscitation.
April 1986, Circulation,
D H Shaffner, and C L Schleien, and R C Koehler, and B Eberle, and R J Traystman
Effect of vest cardiopulmonary resuscitation rate on cardiac output and coronary blood flow.
August 1989, Critical care medicine,
D H Shaffner, and C L Schleien, and R C Koehler, and B Eberle, and R J Traystman
Effects of incomplete chest wall decompression during cardiopulmonary resuscitation on coronary and cerebral perfusion pressures in a porcine model of cardiac arrest.
March 2005, Resuscitation,
D H Shaffner, and C L Schleien, and R C Koehler, and B Eberle, and R J Traystman
Effect of pralidoxime on coronary perfusion pressure during cardiopulmonary resuscitation in a pig model.
September 2019, Clinical and experimental emergency medicine,
D H Shaffner, and C L Schleien, and R C Koehler, and B Eberle, and R J Traystman
[Effect of urokinase on cerebral perfusion in rabbits after cardiopulmonary resuscitation].
November 2013, Zhonghua wei zhong bing ji jiu yi xue,
D H Shaffner, and C L Schleien, and R C Koehler, and B Eberle, and R J Traystman
Effect of urokinase on cerebral perfusion after cardiopulmonary resuscitation in rabbits.
January 2014, European review for medical and pharmacological sciences,
D H Shaffner, and C L Schleien, and R C Koehler, and B Eberle, and R J Traystman
Effect of continuous compressions and 30:2 cardiopulmonary resuscitation on global ventilation/perfusion values during resuscitation in a porcine model.
October 2010, Critical care medicine,
D H Shaffner, and C L Schleien, and R C Koehler, and B Eberle, and R J Traystman
Coronary perfusion pressure during cardiopulmonary resuscitation.
January 1985, The American journal of emergency medicine,
D H Shaffner, and C L Schleien, and R C Koehler, and B Eberle, and R J Traystman
Epinephrine dosage effects on cerebral and myocardial blood flow in an infant swine model of cardiopulmonary resuscitation.
December 1991, Anesthesiology,
Copied contents to your clipboard!