Biomaterial Database

Structure of the murine interferon alpha/beta receptor-encoding gene: high-frequency rearrangements in the interferon-resistant L1210 cell line. 1994

G Lutfalla, and G Uzé

Institut de Génétique Moléculaire, UMR 9942, CNRS, Université Montpellier 1 & 2, France.

The structure of the murine IFNAR gene, encoding the interferon alpha/beta receptor, is reported. The gene has eleven exons dispersed in about 23 kb of genomic DNA. The nature of the rearrangements affecting this gene in interferon-resistant (IFNR) L1210 mutant cell lines is described.

UI	MeSH Term	Description	Entries
D007939	Leukemia L1210	An experimental LYMPHOCYTIC LEUKEMIA of mice.	Leukemia L 1210,L 1210, Leukemia,L1210, Leukemia
D008565	Membrane Proteins	Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.	Cell Membrane Protein,Cell Membrane Proteins,Cell Surface Protein,Cell Surface Proteins,Integral Membrane Proteins,Membrane-Associated Protein,Surface Protein,Surface Proteins,Integral Membrane Protein,Membrane Protein,Membrane-Associated Proteins,Membrane Associated Protein,Membrane Associated Proteins,Membrane Protein, Cell,Membrane Protein, Integral,Membrane Proteins, Integral,Protein, Cell Membrane,Protein, Cell Surface,Protein, Integral Membrane,Protein, Membrane,Protein, Membrane-Associated,Protein, Surface,Proteins, Cell Membrane,Proteins, Cell Surface,Proteins, Integral Membrane,Proteins, Membrane,Proteins, Membrane-Associated,Proteins, Surface,Surface Protein, Cell
D008969	Molecular Sequence Data	Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.	Sequence Data, Molecular,Molecular Sequencing Data,Data, Molecular Sequence,Data, Molecular Sequencing,Sequencing Data, Molecular
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014407	Tumor Cells, Cultured	Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.	Cultured Tumor Cells,Neoplastic Cells, Cultured,Cultured Neoplastic Cells,Cell, Cultured Neoplastic,Cell, Cultured Tumor,Cells, Cultured Neoplastic,Cells, Cultured Tumor,Cultured Neoplastic Cell,Cultured Tumor Cell,Neoplastic Cell, Cultured,Tumor Cell, Cultured
D015321	Gene Rearrangement	The ordered rearrangement of gene regions by DNA recombination such as that which occurs normally during development.	DNA Rearrangement,DNA Rearrangements,Gene Rearrangements,Rearrangement, DNA,Rearrangement, Gene,Rearrangements, DNA,Rearrangements, Gene
D017471	Receptors, Interferon	Specific molecular sites or structures on or in cells with which interferons react or to which they bind in order to modify the function of the cells. Interferons exert their pleiotropic effects through two different receptors. alpha- and beta-interferon crossreact with common receptors, while gamma-interferon initiates its biological effects through its own specific receptor system.	Interferon Receptors,Interferon Receptor,Receptor, Interferon
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D053633	Receptor, Interferon alpha-beta	A ubiquitously expressed heterodimeric receptor that is specific for both INTERFERON-ALPHA and INTERFERON-BETA. It is composed of two subunits referred to as IFNAR1 and IFNAR2. The IFNAR2 subunit is believed to serve as the ligand-binding chain; however both chains are required for signal transduction. The interferon alpha-beta receptor signals through the action of JANUS KINASES such as the TYK2 KINASE.	Interferon alpha-beta Receptor,IFN-alphaR,IFN-alphabetaR,IFNAR1 Subunit, Interferon alpha-beta Receptor,IFNAR2 Subunit, Interferon alpha-beta Receptor,IFNAR2.1 Subunit, Interferon alpha-beta Receptor,IFNAR2.2 Subunit, Interferon alpha-beta Receptor,Interferon alpha Receptor,Interferon alpha Receptors,Interferon alpha-beta Receptor Chain 1,Interferon alpha-beta Receptor Chain 2,Interferon alpha-beta Receptor IFNAR1 Subunit,Interferon alpha-beta Receptor IFNAR2 Subunit,Interferon alpha-beta Receptor-1,Interferon alpha-beta Receptor-2,Interferon alphabeta Receptors,Receptor, Interferon alpha,Type I Interferon Receptor,IFN alphabetaR,IFNAR1 Subunit, Interferon alpha beta Receptor,IFNAR2 Subunit, Interferon alpha beta Receptor,IFNAR2.1 Subunit, Interferon alpha beta Receptor,IFNAR2.2 Subunit, Interferon alpha beta Receptor,Interferon alpha beta Receptor,Interferon alpha beta Receptor 1,Interferon alpha beta Receptor 2,Interferon alpha beta Receptor Chain 1,Interferon alpha beta Receptor Chain 2,Interferon alpha beta Receptor IFNAR1 Subunit,Interferon alpha beta Receptor IFNAR2 Subunit,Receptor, Interferon alpha beta,Receptor-1, Interferon alpha-beta,Receptor-2, Interferon alpha-beta,Receptors, Interferon alpha,Receptors, Interferon alphabeta,alpha Receptor, Interferon,alpha Receptors, Interferon,alpha-beta Receptor-1, Interferon,alpha-beta Receptor-2, Interferon