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The importance of persistent negative symptoms in schizophrenia as a limiting factor in psychosocial and vocational rehabilitation has been increasingly emphasized. As a result, treatment trials and new drug development programs are focusing more attention on negative symptoms. Unfortunately, there is enormous phenomenological overlap between negative symptoms and neuroleptic-induced parkinsonism. We report data from a cohort of 56 clozapine-treated patients demonstrating significant correlations between measures of akinesia and anergia. Despite an average drug washout of over 2 weeks, the persistence of drug-induced parkinsonism can confound the assessment of therapeutic drug effects on negative symptoms.
J M Kane, and
A Z Safferman, and
S Pollack, and
C Johns, and
S Szymanski, and
M Kronig, and
J A Lieberman
March 1995,
Psychopharmacology,
J M Kane, and
A Z Safferman, and
S Pollack, and
C Johns, and
S Szymanski, and
M Kronig, and
J A Lieberman
January 2017,
Rivista di psichiatria,
J M Kane, and
A Z Safferman, and
S Pollack, and
C Johns, and
S Szymanski, and
M Kronig, and
J A Lieberman
June 1997,
Canadian journal of psychiatry. Revue canadienne de psychiatrie,
J M Kane, and
A Z Safferman, and
S Pollack, and
C Johns, and
S Szymanski, and
M Kronig, and
J A Lieberman
January 2000,
Psychopathology,
J M Kane, and
A Z Safferman, and
S Pollack, and
C Johns, and
S Szymanski, and
M Kronig, and
J A Lieberman
January 1998,
Psychopharmacology bulletin,
J M Kane, and
A Z Safferman, and
S Pollack, and
C Johns, and
S Szymanski, and
M Kronig, and
J A Lieberman
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J M Kane, and
A Z Safferman, and
S Pollack, and
C Johns, and
S Szymanski, and
M Kronig, and
J A Lieberman
January 1993,
Psychopharmacology bulletin,
J M Kane, and
A Z Safferman, and
S Pollack, and
C Johns, and
S Szymanski, and
M Kronig, and
J A Lieberman
March 1996,
Psychopharmacology,
J M Kane, and
A Z Safferman, and
S Pollack, and
C Johns, and
S Szymanski, and
M Kronig, and
J A Lieberman
October 1975,
Der Nervenarzt,
J M Kane, and
A Z Safferman, and
S Pollack, and
C Johns, and
S Szymanski, and
M Kronig, and
J A Lieberman
January 2004,
Nursing standard (Royal College of Nursing (Great Britain) : 1987),
