-transparent.png){kind=logo}
The replacement of the imidazole ring of cimetidine with a bicyclic system (imidazo[1,2-a]pyridine), reported in the literature, produced compounds endowed with potent antiulcer activity. In this paper we describe the synthesis of imidazo [2,1-b]thiazoles and thiazolines bearing the side chain of metiamide, cimetidine and ranitidine: the compounds obtained, tested on gastric lesions induced in rats by ethanol and by stress, were devoid of antiulcer activity.
Related Publications
A Andreani, and
M Rambaldi, and
A Leoni, and
A Locatelli, and
G Pifferi
November 2009,
ChemMedChem,
A Andreani, and
M Rambaldi, and
A Leoni, and
A Locatelli, and
G Pifferi
May 1988,
Il Farmaco; edizione scientifica,
A Andreani, and
M Rambaldi, and
A Leoni, and
A Locatelli, and
G Pifferi
December 1980,
Journal of medicinal chemistry,
A Andreani, and
M Rambaldi, and
A Leoni, and
A Locatelli, and
G Pifferi
July 2012,
Carbohydrate research,
A Andreani, and
M Rambaldi, and
A Leoni, and
A Locatelli, and
G Pifferi
October 2012,
Organic & biomolecular chemistry,
A Andreani, and
M Rambaldi, and
A Leoni, and
A Locatelli, and
G Pifferi
September 2000,
Organic letters,
A Andreani, and
M Rambaldi, and
A Leoni, and
A Locatelli, and
G Pifferi
August 2022,
RSC advances,
A Andreani, and
M Rambaldi, and
A Leoni, and
A Locatelli, and
G Pifferi
February 2024,
Drug development research,
A Andreani, and
M Rambaldi, and
A Leoni, and
A Locatelli, and
G Pifferi
July 2016,
Acta poloniae pharmaceutica,
A Andreani, and
M Rambaldi, and
A Leoni, and
A Locatelli, and
G Pifferi
January 2022,
Medicinal chemistry (Shariqah (United Arab Emirates)),
