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Men from the Multicenter AIDS Cohort Study were classified as "susceptible" and "resistant" to HIV infection. Resistant men were still HIV antibody negative in 1993 and were estimated to have had > 45 different anal intercourse partners (median, 92; range, 46-504) in the 2.5 years before visit 2 (1985). Susceptible men were seroconverters who were estimated to have had < 13 different anal partners (median, 4; range, 0-12). Leukocyte groups were compared between the two groups of men. Values were excluded for 12 months before the first antibody-positive visit in the susceptible men. White blood cells, polymorphonuclear neutrophils, total lymphocyte count, CD8+ percentage and number, and CD3+ and CD4+ number were higher in the resistant men. Logistic regression analyses were used to develop 50 bivariate models. Higher levels of neutrophils and CD8+ cells were included in four of the six best-fitting bivariate models, suggesting that each is associated with resistance to HIV-1 infection. These results support the hypothesis that CD8+ cells may modulate the outcome of HIV-1 exposure.
R Detels, and
Z Liu, and
K Hennessey, and
J Kan, and
B R Visscher, and
J M Taylor, and
D R Hoover, and
C R Rinaldo, and
J P Phair, and
A J Saah
July 1995,
Nature medicine,
R Detels, and
Z Liu, and
K Hennessey, and
J Kan, and
B R Visscher, and
J M Taylor, and
D R Hoover, and
C R Rinaldo, and
J P Phair, and
A J Saah
January 1993,
Journal of acquired immune deficiency syndromes,
R Detels, and
Z Liu, and
K Hennessey, and
J Kan, and
B R Visscher, and
J M Taylor, and
D R Hoover, and
C R Rinaldo, and
J P Phair, and
A J Saah
August 1991,
Lancet (London, England),
R Detels, and
Z Liu, and
K Hennessey, and
J Kan, and
B R Visscher, and
J M Taylor, and
D R Hoover, and
C R Rinaldo, and
J P Phair, and
A J Saah
August 2008,
AIDS (London, England),
R Detels, and
Z Liu, and
K Hennessey, and
J Kan, and
B R Visscher, and
J M Taylor, and
D R Hoover, and
C R Rinaldo, and
J P Phair, and
A J Saah
January 1990,
Journal of acquired immune deficiency syndromes,
R Detels, and
Z Liu, and
K Hennessey, and
J Kan, and
B R Visscher, and
J M Taylor, and
D R Hoover, and
C R Rinaldo, and
J P Phair, and
A J Saah
February 1990,
Neurology,
R Detels, and
Z Liu, and
K Hennessey, and
J Kan, and
B R Visscher, and
J M Taylor, and
D R Hoover, and
C R Rinaldo, and
J P Phair, and
A J Saah
February 1998,
Journal of clinical and experimental neuropsychology,
R Detels, and
Z Liu, and
K Hennessey, and
J Kan, and
B R Visscher, and
J M Taylor, and
D R Hoover, and
C R Rinaldo, and
J P Phair, and
A J Saah
September 1998,
Lancet (London, England),
R Detels, and
Z Liu, and
K Hennessey, and
J Kan, and
B R Visscher, and
J M Taylor, and
D R Hoover, and
C R Rinaldo, and
J P Phair, and
A J Saah
September 1996,
Science (New York, N.Y.),
R Detels, and
Z Liu, and
K Hennessey, and
J Kan, and
B R Visscher, and
J M Taylor, and
D R Hoover, and
C R Rinaldo, and
J P Phair, and
A J Saah
December 1993,
JAMA,
