The author discussed some points where the staff in clinical departments could cooperate with the tissue pathology department to facilitate good quality control, (hereafter abbreviated as QC) from the stand point of a staff in internal medicine or gastroenterology. Remarks on general matters such as necessity of QC system at the ward where nurses are usually engaged in the treatment of the specimens for clinical laboratory. As to QC on tissue pathological diagnosis, inter-hospital surveillance is inevitably important. However, this has not been done because of defects in philosophy of Japanese medical insurance and in facts of medical education. At postmortem examination, the clinician would like to expect the pathologist to have a thoughtful consideration to convenience of the family of the dead. The tissue examinations of the biopsy specimens from GI endoscopy in the author's department are summarized as follows. In 1993, biopsy rates was 26.1% among 1726 patients done upper GI endoscopy. It was 42.4% in 536 patients done lower GI endoscopy. Group IV & V in the histological grade of malignancy account for 13.1% of 450 cases in upper GI specimens. Group 4 & 5 account for 16.3% of 226 cases in lower GI specimens. The frequency of specimens with malignancy taken by each endoscopist did not reveal any difference in the technical skill of each endoscopists, neither did the average number of specimens obtained in one occasion by each endoscopist. On 28 patients, biopsies were done in multiple occasions in a year. The rate of false negative in initial biopsy was 1.4% in 445 cases with which neoplasms were suspected.(ABSTRACT TRUNCATED AT 250 WORDS)