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The aim of this study was to investigate the effect of unilateral nephrectomy on the pharmacokinetics of gentamicin. The study was carried out on 19 male rabbits. Gentamicin was injected i.v. at a dose of 3.5 mg/kg twice daily during 5 days, before operation and after 2 weeks as well as 3 months from nephrectomy. Blood for the assays was collected within 6 hours after the drug administration on the 5th day of each study stage. The immunofluorescence polarization method was employed for determination of gentamicin concentration. The one-compartment open model was used for calculations. It was shown that in unilaterally nephrectomized rabbits the elimination of gentamicin can be significantly impaired during the whole study period.
M Droździk, and
T Kardel-Mizerska, and
B Gawrońska-Szklarz, and
J Wójcicki, and
B Krasowska, and
L Rózewicka
August 1978,
Antimicrobial agents and chemotherapy,
M Droździk, and
T Kardel-Mizerska, and
B Gawrońska-Szklarz, and
J Wójcicki, and
B Krasowska, and
L Rózewicka
October 1998,
Journal of the American Veterinary Medical Association,
M Droździk, and
T Kardel-Mizerska, and
B Gawrońska-Szklarz, and
J Wójcicki, and
B Krasowska, and
L Rózewicka
September 1995,
Journal of the South African Veterinary Association,
M Droździk, and
T Kardel-Mizerska, and
B Gawrońska-Szklarz, and
J Wójcicki, and
B Krasowska, and
L Rózewicka
April 1995,
Journal of veterinary pharmacology and therapeutics,
M Droździk, and
T Kardel-Mizerska, and
B Gawrońska-Szklarz, and
J Wójcicki, and
B Krasowska, and
L Rózewicka
August 1985,
Antimicrobial agents and chemotherapy,
M Droździk, and
T Kardel-Mizerska, and
B Gawrońska-Szklarz, and
J Wójcicki, and
B Krasowska, and
L Rózewicka
January 1974,
Acta Universitatis Carolinae. Medica,
M Droździk, and
T Kardel-Mizerska, and
B Gawrońska-Szklarz, and
J Wójcicki, and
B Krasowska, and
L Rózewicka
January 1975,
Patologicheskaia fiziologiia i eksperimental'naia terapiia,
M Droździk, and
T Kardel-Mizerska, and
B Gawrońska-Szklarz, and
J Wójcicki, and
B Krasowska, and
L Rózewicka
January 1991,
Nephron,
M Droździk, and
T Kardel-Mizerska, and
B Gawrońska-Szklarz, and
J Wójcicki, and
B Krasowska, and
L Rózewicka
December 1988,
American journal of veterinary research,
M Droździk, and
T Kardel-Mizerska, and
B Gawrońska-Szklarz, and
J Wójcicki, and
B Krasowska, and
L Rózewicka
January 1982,
Methods and findings in experimental and clinical pharmacology,
