Electrical analogy of diastolic pressure difference between left atrium and ventricle. 1994

S Haruyama, and H Mori, and L M Wan, and Y Shinozaki, and H Sakamoto, and H Okino
Department of Physiology, Tokai University School of Medicine, Kanagawa, Japan.

We proposed a mathematical model to describe the early filling process of the left ventricle and applied the model to in vivo experiments. The solution of a second-order differential equation indicated that the pressure difference between the left atrium and ventricle during ventricular filling (PD) could be explained by a transient response, i.e. decremental oscillation, in an LCR circuit. Thereafter, we analysed the sequence of PD during vagal stimulation with two catheter-tip manometers in 12 anaesthetised dogs and evaluated changes in the parameters of the system under various haemodynamic conditions. The values of omega n and zeta were quite stable among beats within an episode of vagal stimulation, between episodes and even among dogs, despite the changes in haemodynamic variables. Pericardiotomy and partial discommunication of the mitral valve with the left ventricular free wall by cutting the mitral chordal tendons decreased omega n and increased zeta, mainly because of the increase in CLV. Occlusion of the coronary vascular beds with large numbers of microspheres increased omega n and decreased zeta, mainly because of the decrease in CLV. Mitral obstruction with an inflated balloon (increase in R) abolished the oscillatory changes and produced an exponential decay sequence of PD. In conclusion, both the logical and experimental approaches indicated that the sequence of PD could be considered as decremental oscillation in the LCR circuit and the parameters omega n and zeta could be good indices of the diastolic property of the left ventricle.

UI MeSH Term Description Entries
D008433 Mathematics The deductive study of shape, quantity, and dependence. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed) Mathematic
D008955 Models, Cardiovascular Theoretical representations that simulate the behavior or activity of the cardiovascular system, processes, or phenomena; includes the use of mathematical equations, computers and other electronic equipment. Cardiovascular Model,Cardiovascular Models,Model, Cardiovascular
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D003187 Compliance Distensibility measure of a chamber such as the lungs (LUNG COMPLIANCE) or bladder. Compliance is expressed as a change in volume per unit change in pressure.
D004285 Dogs The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065) Canis familiaris,Dog
D004560 Electricity The physical effects involving the presence of electric charges at rest and in motion.
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D016275 Atrial Function The hemodynamic and electrophysiological action of the HEART ATRIA. Atrial Functions,Function, Atrial,Functions, Atrial
D016277 Ventricular Function, Left The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance. Left Ventricular Function,Function, Left Ventricular,Functions, Left Ventricular,Left Ventricular Functions,Ventricular Functions, Left

Related Publications

S Haruyama, and H Mori, and L M Wan, and Y Shinozaki, and H Sakamoto, and H Okino
October 1959, American heart journal,
S Haruyama, and H Mori, and L M Wan, and Y Shinozaki, and H Sakamoto, and H Okino
January 1970, British heart journal,
S Haruyama, and H Mori, and L M Wan, and Y Shinozaki, and H Sakamoto, and H Okino
January 1973, Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
S Haruyama, and H Mori, and L M Wan, and Y Shinozaki, and H Sakamoto, and H Okino
July 1966, The American journal of physiology,
S Haruyama, and H Mori, and L M Wan, and Y Shinozaki, and H Sakamoto, and H Okino
January 1974, Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
S Haruyama, and H Mori, and L M Wan, and Y Shinozaki, and H Sakamoto, and H Okino
September 1967, Thorax,
S Haruyama, and H Mori, and L M Wan, and Y Shinozaki, and H Sakamoto, and H Okino
July 1967, The American journal of physiology,
S Haruyama, and H Mori, and L M Wan, and Y Shinozaki, and H Sakamoto, and H Okino
January 1971, Grudnaia khirurgiia (Moscow, Russia),
S Haruyama, and H Mori, and L M Wan, and Y Shinozaki, and H Sakamoto, and H Okino
February 1962, The American journal of cardiology,
S Haruyama, and H Mori, and L M Wan, and Y Shinozaki, and H Sakamoto, and H Okino
September 1971, Circulation research,
Copied contents to your clipboard!