Visual field analysis using artificial neural networks. 1994

S E Spenceley, and D B Henson, and D R Bull
Department of Optometry and Vision Sciences, University of Wales College of Cardiff, UK.

There have been several reports on the application of artificial neural networks (ANNs) to visual field classification. While these have demonstrated that neural networks can be used with good results they have not explored the effects that the training set can have upon network performance nor emphasized the unique value of ANNs in visual field analysis. This paper considers the problem of differentiating normal and glaucomatous visual fields and explores different training set characteristics using field data collected from a Henson CFS2000 perimeter. Training set properties including size, balance between normals and glaucomas, extent of field loss and the spatial location of glaucomatous defects are explored. A multilayer network with 132 input nodes, 20 hidden layer nodes and 2 output nodes in trained using an error backpropagation algorithm. Both sensitivity and specificity are measured during testing. The results demonstrate that large random sets are better than small random sets since sensitivity improves with size and specificity is not adversely affected. The variability in performance also reduces as training set size increases. In addition, sets that are biased towards glaucoma examples are more sensitive and less specific, while sets biased with normal examples are more specific and less sensitive than balanced sets. Thus large training sets with class balance are generally desirable for good sensitivities and specificities. The actual glaucoma examples contained in the set are also important. A training set deficient in examples has no detrimental effect on sensitivity or specificity. The spatial distribution of defects is also crucial. Spatially biased sets are unable to recognize defects that occur in locations where no previous defect has been presented while more balanced sets lead to better performance. In conclusion the 'ideal' training set should contain many examples of early defects that represent the full range of locations where these defects may occur.

UI MeSH Term Description Entries
D011214 Practice, Psychological Performance of an act one or more times, with a view to its fixation or improvement; any performance of an act or behavior that leads to learning. Practice (Psychology),Practice, Psychology,Practicing, Psychological,Practicing, Psychology,Psychological Practice,Psychological Practicing,Psychology Practice,Psychology Practicing
D005901 Glaucoma An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed) Glaucomas
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000465 Algorithms A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task. Algorithm
D012680 Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed) Specificity,Sensitivity,Specificity and Sensitivity
D014794 Visual Fields The total area or space visible in a person's peripheral vision with the eye looking straightforward. Field, Visual,Fields, Visual,Visual Field
D016571 Neural Networks, Computer A computer architecture, implementable in either hardware or software, modeled after biological neural networks. Like the biological system in which the processing capability is a result of the interconnection strengths between arrays of nonlinear processing nodes, computerized neural networks, often called perceptrons or multilayer connectionist models, consist of neuron-like units. A homogeneous group of units makes up a layer. These networks are good at pattern recognition. They are adaptive, performing tasks by example, and thus are better for decision-making than are linear learning machines or cluster analysis. They do not require explicit programming. Computational Neural Networks,Connectionist Models,Models, Neural Network,Neural Network Models,Neural Networks (Computer),Perceptrons,Computational Neural Network,Computer Neural Network,Computer Neural Networks,Connectionist Model,Model, Connectionist,Model, Neural Network,Models, Connectionist,Network Model, Neural,Network Models, Neural,Network, Computational Neural,Network, Computer Neural,Network, Neural (Computer),Networks, Computational Neural,Networks, Computer Neural,Networks, Neural (Computer),Neural Network (Computer),Neural Network Model,Neural Network, Computational,Neural Network, Computer,Neural Networks, Computational,Perceptron
D058609 Visual Field Tests Method of measuring and mapping the scope of vision, from central to peripheral of each eye. Automated Perimetry Exam,Campimetry,Perimetry,Tangent Screen Exam,Visual Field Exam,Automated Perimetry Exams,Campimetries,Exam, Automated Perimetry,Exam, Tangent Screen,Exam, Visual Field,Exams, Automated Perimetry,Exams, Tangent Screen,Exams, Visual Field,Field Exam, Visual,Field Exams, Visual,Field Test, Visual,Field Tests, Visual,Perimetries,Perimetry Exam, Automated,Perimetry Exams, Automated,Screen Exam, Tangent,Screen Exams, Tangent,Tangent Screen Exams,Test, Visual Field,Tests, Visual Field,Visual Field Exams,Visual Field Test

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