[Cell Dyn 3000: technical performance and applications in hematologic pathology]. 1994

H Merle-Béral
Département d'Hématologie, CHU Pitié-Salpêtrière, Paris, France.

The Abbott Cell-Dyn (CD) 3000 is an automatic analyser, designed to give cell blood counts (CBC) and white blood differential (WBCD) by 4 angels diffraction analysis. Evaluation was performed by comparison between results obtained by CD and those obtained by Technicon H1 and by microscopic examination. Technical performances as reproducibility, linearity, carryover were quite well acceptable. On normal samples, neutrophils (NE), lymphocytes (LY) and eosinophils (EO) were found to correlate with optical method with coefficient (R) values higher than 0.9. Weaker R coefficients were found for monocytes (MO) and basophils (BA), however it didn't involve clinical consequences. Significant threshold for immature granulocytes (IG) and variant lymphocytes (VL) flags were built. By using those, a false positive rate of 7% was shown. In hematological diseases, no false negative was detected because all samples were flagged. However, no acute lymphoblastic leukemia (ALL) was studied, so the detection of lymphoblast, as known as a real difficulty for analyser, was not yet evaluated. Blasts in acute myeloblastic leukemia (AML) and hairy cells were both noticed by CD. Moreover, for chronic lymphocytic leukemia (CLL), three groups were described, according to the flags released. Knowing its performances and its limits, CD is a good analyser usable in an all round or a hematological laboratory with high number of WBCD per day.

UI MeSH Term Description Entries
D011237 Predictive Value of Tests In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test. Negative Predictive Value,Positive Predictive Value,Predictive Value Of Test,Predictive Values Of Tests,Negative Predictive Values,Positive Predictive Values,Predictive Value, Negative,Predictive Value, Positive
D001772 Blood Cell Count The number of LEUKOCYTES and ERYTHROCYTES per unit volume in a sample of venous BLOOD. A complete blood count (CBC) also includes measurement of the HEMOGLOBIN; HEMATOCRIT; and ERYTHROCYTE INDICES. Blood Cell Number,Blood Count, Complete,Blood Cell Counts,Blood Cell Numbers,Blood Counts, Complete,Complete Blood Count,Complete Blood Counts,Count, Blood Cell,Count, Complete Blood,Counts, Blood Cell,Counts, Complete Blood,Number, Blood Cell,Numbers, Blood Cell
D005069 Evaluation Studies as Topic Works about studies that determine the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies. Critique,Evaluation Indexes,Evaluation Methodology,Evaluation Report,Evaluation Research,Methodology, Evaluation,Pre-Post Tests,Qualitative Evaluation,Quantitative Evaluation,Theoretical Effectiveness,Use-Effectiveness,Critiques,Effectiveness, Theoretical,Evaluation Methodologies,Evaluation Reports,Evaluation, Qualitative,Evaluation, Quantitative,Evaluations, Qualitative,Evaluations, Quantitative,Indexes, Evaluation,Methodologies, Evaluation,Pre Post Tests,Pre-Post Test,Qualitative Evaluations,Quantitative Evaluations,Report, Evaluation,Reports, Evaluation,Research, Evaluation,Test, Pre-Post,Tests, Pre-Post,Use Effectiveness
D006402 Hematologic Diseases Disorders of the blood and blood forming tissues. Blood Diseases,Hematological Diseases,Blood Disease,Disease, Blood,Disease, Hematologic,Disease, Hematological,Diseases, Blood,Diseases, Hematologic,Diseases, Hematological,Hematologic Disease,Hematological Disease
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001322 Autoanalysis Method of analyzing chemicals using automation. Autoanalyses

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