Biomaterial Database

Effects of cocaine and GBR-12909 on brain stimulation reward. 1994

C S Maldonado-Irizarry, and J R Stellar, and A E Kelley

Department of Psychology, Northeastern University, Boston, MA 02115.

Cocaine and GBR-12909, two dopamine reuptake blockers, were administered in a multiple current rate-frequency curve-shift test of intracranial self-stimulation (ICSS) reward in rats with medial forebrain bundle (MFB) electrodes. Acute injections of cocaine (0, 5, 15, 30 mg/kg, IP) increased ICSS reward at all currents (501, 316, 200 microAmps) as measured by decrease half-maximal frequency threshold. Cocaine also increased operant motor performance but only at the low current. In addition, cocaine increased dynamic interval at the highest dose at all currents. Similar treatment with GBR-12909 (0, 5, 10, 20 mg/kg, IP) significantly increased ICSS reward (decreased threshold) especially at the medium dose in all currents and had no significant effects on operant motor performance or dynamic interval. The major novel finding of the present study is that the rewarding effects of both drugs was not dependent on the choice of stimulation current, which is discussed as simplifying future psychophysical testing of psychostimulant drugs in the ICSS rate-frequency curve-shift paradigm.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008474	Medial Forebrain Bundle	A complex group of fibers arising from the basal olfactory regions, the periamygdaloid region, and the septal nuclei, and passing to the lateral hypothalamus. Some fibers continue into the tegmentum.	Median Forebrain Bundle,Bundle, Medial Forebrain,Bundle, Median Forebrain,Bundles, Medial Forebrain,Bundles, Median Forebrain,Forebrain Bundle, Medial,Forebrain Bundle, Median,Forebrain Bundles, Medial,Forebrain Bundles, Median,Medial Forebrain Bundles,Median Forebrain Bundles
D009043	Motor Activity	Body movements of a human or an animal as a behavioral phenomenon.	Activities, Motor,Activity, Motor,Motor Activities
D010879	Piperazines	Compounds that are derived from PIPERAZINE.
D001921	Brain	The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.	Encephalon
D003042	Cocaine	An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.	Cocaine HCl,Cocaine Hydrochloride,HCl, Cocaine,Hydrochloride, Cocaine
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004567	Electrodes, Implanted	Surgically placed electric conductors through which ELECTRIC STIMULATION is delivered to or electrical activity is recorded from a specific point inside the body.	Implantable Electrodes,Implantable Stimulation Electrodes,Implanted Electrodes,Implanted Stimulation Electrodes,Electrode, Implantable,Electrode, Implantable Stimulation,Electrode, Implanted,Electrode, Implanted Stimulation,Electrodes, Implantable,Electrodes, Implantable Stimulation,Electrodes, Implanted Stimulation,Implantable Electrode,Implantable Stimulation Electrode,Implanted Electrode,Implanted Stimulation Electrode,Stimulation Electrode, Implantable,Stimulation Electrode, Implanted,Stimulation Electrodes, Implantable,Stimulation Electrodes, Implanted
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012201	Reward	An object or a situation that can serve to reinforce a response, to satisfy a motive, or to afford pleasure.	Rewards