BIOMAT Database Logo BIOMAT Database Logo

Behavioral responses to intravenous meta-chlorophenylpiperazine in patients with seasonal affective disorder and control subjects before and after phototherapy. 1994

F M Jacobsen, and E A Mueller, and N E Rosenthal, and S Rogers, and J L Hill, and D L Murphy
Laboratory of Clinical Science, National Institute of Mental Health (NIMH), Bethesda, MD 20892.

A comparison of the baseline and post-infusion effects of the serotonin agonist meta-chlorophenylpiperazine (m-CPP) in 10 patients with seasonal affective disorder (SAD) and 11 healthy control subjects revealed significantly different subjective response profiles between the groups. Several baseline and m-CPP-stimulated responses in symptoms putatively related to serotonergic function changed significantly after a week's exposure to phototherapy in the SAD patients but not the control subjects. Before phototherapy, depressed patients with SAD reported activation-euphoria responses to m-CPP and significant decreases in carbohydrate hunger, but insignificant changes in feeling slowed or sleepy, while control subjects reported no mood or appetite changes but significant increases in feeling slowed down following m-CPP. After phototherapy, which led to a significant reduction in baseline depressive symptom rating to near-euthymic levels in the SAD patients, almost all of the patients' responses to m-CPP were normalized and no longer differed from the control subjects' responses. These results provide evidence of a possible dysregulation in serotonergic neurotransmission in depressed SAD patients that normalizes following treatment with phototherapy.

UI MeSH Term Description Entries
D007275 Injections, Intravenous Injections made into a vein for therapeutic or experimental purposes. Intravenous Injections,Injection, Intravenous,Intravenous Injection
D008297 Male Males
D010789 Phototherapy Treatment of disease by exposure to light, especially by variously concentrated light rays or specific wavelengths. Blue Light Therapy,Blue-light Therapy,Light Therapy,Photoradiation Therapy,Red Light Phototherapy,Therapy, Photoradiation,Blue Light Therapies,Blue-light Therapies,Light Phototherapies, Red,Light Phototherapy, Red,Light Therapies,Light Therapies, Blue,Light Therapy, Blue,Photoradiation Therapies,Phototherapies,Phototherapies, Red Light,Phototherapy, Red Light,Red Light Phototherapies,Therapies, Blue Light,Therapies, Blue-light,Therapies, Light,Therapies, Photoradiation,Therapy, Blue Light,Therapy, Blue-light,Therapy, Light
D010879 Piperazines Compounds that are derived from PIPERAZINE.
D011795 Surveys and Questionnaires Collections of data obtained from voluntary subjects. The information usually takes the form of answers to questions, or suggestions. Community Survey,Nonrespondent,Questionnaire,Questionnaires,Respondent,Survey,Survey Method,Survey Methods,Surveys,Baseline Survey,Community Surveys,Methodology, Survey,Nonrespondents,Questionnaire Design,Randomized Response Technique,Repeated Rounds of Survey,Respondents,Survey Methodology,Baseline Surveys,Design, Questionnaire,Designs, Questionnaire,Methods, Survey,Questionnaire Designs,Questionnaires and Surveys,Randomized Response Techniques,Response Technique, Randomized,Response Techniques, Randomized,Survey, Baseline,Survey, Community,Surveys, Baseline,Surveys, Community,Techniques, Randomized Response
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D012701 Serotonin A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator. 5-HT,5-Hydroxytryptamine,3-(2-Aminoethyl)-1H-indol-5-ol,Enteramine,Hippophaine,Hydroxytryptamine,5 Hydroxytryptamine
D016574 Seasonal Affective Disorder A syndrome characterized by depressions that recur annually at the same time each year, usually during the winter months. Other symptoms include anxiety, irritability, decreased energy, increased appetite (carbohydrate cravings), increased duration of sleep, and weight gain. SAD (seasonal affective disorder) can be treated by daily exposure to bright artificial lights (PHOTOTHERAPY), during the season of recurrence. Seasonal Mood Disorder,Winter Depression,Seasonal Affective Disorders,Affective Disorder, Seasonal,Depression, Winter,Disorder, Seasonal Affective,Disorder, Seasonal Mood,Mood Disorder, Seasonal,Seasonal Mood Disorders

Related Publications

F M Jacobsen, and E A Mueller, and N E Rosenthal, and S Rogers, and J L Hill, and D L Murphy
Effects of meta-chlorophenylpiperazine infusions in patients with seasonal affective disorder and healthy control subjects. Diurnal responses and nocturnal regulatory mechanisms.
April 1997, Archives of general psychiatry,
F M Jacobsen, and E A Mueller, and N E Rosenthal, and S Rogers, and J L Hill, and D L Murphy
Hormonal and subjective responses to intravenous m-chlorophenylpiperazine in women with seasonal affective disorder.
March 1998, Archives of general psychiatry,
F M Jacobsen, and E A Mueller, and N E Rosenthal, and S Rogers, and J L Hill, and D L Murphy
[Daily sensation of hunger, before and after phototherapy, in subjects with depression-type seasonal affective disorder].
January 2001, La Clinica terapeutica,
F M Jacobsen, and E A Mueller, and N E Rosenthal, and S Rogers, and J L Hill, and D L Murphy
Pituitary hormone responses to meta-chlorophenylpiperazine in panic disorder and healthy control subjects.
April 1991, Psychiatry research,
F M Jacobsen, and E A Mueller, and N E Rosenthal, and S Rogers, and J L Hill, and D L Murphy
Hormonal responses to the administration of m-chlorophenylpiperazine in patients with seasonal affective disorder and controls.
May 1995, Biological psychiatry,
F M Jacobsen, and E A Mueller, and N E Rosenthal, and S Rogers, and J L Hill, and D L Murphy
[Seasonal affective disorder and phototherapy].
January 1990, Psychiatria polska,
F M Jacobsen, and E A Mueller, and N E Rosenthal, and S Rogers, and J L Hill, and D L Murphy
Seasonal affective disorder and phototherapy.
January 1985, Annals of the New York Academy of Sciences,
F M Jacobsen, and E A Mueller, and N E Rosenthal, and S Rogers, and J L Hill, and D L Murphy
Seasonal variation in behavioral responses to m-CPP in patients with seasonal affective disorder and controls.
April 1993, Biological psychiatry,
F M Jacobsen, and E A Mueller, and N E Rosenthal, and S Rogers, and J L Hill, and D L Murphy
Neuroendocrine and behavioral responses to intravenous m-chlorophenylpiperazine (mCPP) in depressed patients and healthy comparison subjects.
November 1994, The American journal of psychiatry,
F M Jacobsen, and E A Mueller, and N E Rosenthal, and S Rogers, and J L Hill, and D L Murphy
Phototherapy of seasonal affective disorder.
March 1991, The Japanese journal of psychiatry and neurology,
Copied contents to your clipboard!