Biomaterial Database

Imaging of abdominal inflammation using other radioisotope techniques. 1994

M Vorne

Lahti Central Hospital, Finland.

99mTc-HMPAO-labelled white cell scanning is compared with other radionuclide techniques in this contribution. The sensitivity and specificity using both 111In and 99mTc-HMPAO-labelled leucocytes are comparably high. Both imaging methods are therefore suitable for imaging inflammation. However, images are available more quickly using 99mTc-HMPAO; their quality is superior and the radiation dose is lower. 111In is beneficial for chronic infections. 67Ga citrate is less specific for inflammation, since it also localizes in tumours, but it is useful in chronic infection. 99mTc nanocolloid has not been found suitable for imaging abdominal inflammation, but more so for bone and joint diseases. Comparisons of 99mTc-HMPAO leucocytes with 123I-labelled monoclonal antibodies show poorer results using the monoclonal antibody because of non-specific binding to plasma proteins. Visualization of lesions is generally poorer using 99mTC-HIG than 99mTc-HMPAO leucocytes and is less sensitive and specific. Few reports using 99mTc-labelled monoclonal antibodies are available. Early results are promising and more specific antibodies may be available in the future. Synthetic chemotactic peptides offer a novel approach to the detection of infection. However, at present the recommended method for imaging acute abdominal inflammation is 99mTc-HMPAO leucocytes.

UI	MeSH Term	Description	Entries
D007136	Immunoglobulins	Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.	Globulins, Immune,Immune Globulin,Immune Globulins,Immunoglobulin,Globulin, Immune
D007205	Indium Radioisotopes	Unstable isotopes of indium that decay or disintegrate emitting radiation. In atoms with atomic weights 106-112, 113m, 114, and 116-124 are radioactive indium isotopes.	Radioisotopes, Indium
D007249	Inflammation	A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	Innate Inflammatory Response,Inflammations,Inflammatory Response, Innate,Innate Inflammatory Responses
D007457	Iodine Radioisotopes	Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.	Radioisotopes, Iodine
D007962	Leukocytes	White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).	Blood Cells, White,Blood Corpuscles, White,White Blood Cells,White Blood Corpuscles,Blood Cell, White,Blood Corpuscle, White,Corpuscle, White Blood,Corpuscles, White Blood,Leukocyte,White Blood Cell,White Blood Corpuscle
D010091	Oximes	Compounds that contain the radical R2C	Aldoximes,Hydroxyimino Compounds,Ketoxime,Ketoximes,Oxime,Compounds, Hydroxyimino
D011877	Radionuclide Imaging	The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.	Gamma Camera Imaging,Radioisotope Scanning,Scanning, Radioisotope,Scintigraphy,Scintiphotography,Imaging, Gamma Camera,Imaging, Radionuclide
D003947	Diagnostic Techniques, Radioisotope	Any diagnostic evaluation using radioactive (unstable) isotopes. This diagnosis includes many nuclear medicine procedures as well as radioimmunoassay tests.	Diagnostic Technic, Radioisotope,Diagnostic Technics, Radioisotope,Diagnostic Technique, Radioisotope,Radioisotope Diagnostic Technic,Radioisotope Diagnostic Technics,Radioisotope Diagnostic Technique,Radioisotope Diagnostic Techniques,Technic, Radioisotope Diagnostic,Technics, Radioisotope Diagnostic,Technique, Radioisotope Diagnostic,Techniques, Radioisotope Diagnostic
D005710	Gallium Radioisotopes	Unstable isotopes of gallium that decay or disintegrate emitting radiation. Ga atoms with atomic weights 63-68, 70 and 72-76 are radioactive gallium isotopes.	Radioisotopes, Gallium
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man