-transparent.png){kind=logo}
CD28 interaction with B7 molecules, expressed on the membranes of antigen-presenting cells, co-stimulates cytokine production, T-cell proliferation and generation of cytotoxic lymphocytes. The expression of CD28 markers on CD4+ and CD8+ lymphocytes was studied in a group of subjects at various stages of HIV infection. A reduction in the percentage of CD28-bearing CD4+ and CD8+ cell subsets was observed during the asymptomatic stage of the disease. This reduction was more pronounced in AIDS than in non-AIDS patients. At the same time, an increase in the absolute CD8+CD28- cell number (greater in stage A than in stage B and C subjects) was observed in HIV-infected patients. The finding of an altered pattern of CD28 expression on T cells might per se explain certain early defects in the cytokine pattern and in the immune response peculiar to HIV-infected patients.
A Caruso, and
A Cantalamessa, and
S Licenziati, and
L Peroni, and
E Prati, and
F Martinelli, and
A D Canaris, and
S Folghera, and
R Gorla, and
A Balsari
March 1994,
Journal of acquired immune deficiency syndromes,
A Caruso, and
A Cantalamessa, and
S Licenziati, and
L Peroni, and
E Prati, and
F Martinelli, and
A D Canaris, and
S Folghera, and
R Gorla, and
A Balsari
July 2005,
AIDS (London, England),
A Caruso, and
A Cantalamessa, and
S Licenziati, and
L Peroni, and
E Prati, and
F Martinelli, and
A D Canaris, and
S Folghera, and
R Gorla, and
A Balsari
May 2008,
AIDS (London, England),
A Caruso, and
A Cantalamessa, and
S Licenziati, and
L Peroni, and
E Prati, and
F Martinelli, and
A D Canaris, and
S Folghera, and
R Gorla, and
A Balsari
April 2004,
Experimental gerontology,
A Caruso, and
A Cantalamessa, and
S Licenziati, and
L Peroni, and
E Prati, and
F Martinelli, and
A D Canaris, and
S Folghera, and
R Gorla, and
A Balsari
January 2013,
Terapevticheskii arkhiv,
A Caruso, and
A Cantalamessa, and
S Licenziati, and
L Peroni, and
E Prati, and
F Martinelli, and
A D Canaris, and
S Folghera, and
R Gorla, and
A Balsari
June 1995,
AIDS (London, England),
A Caruso, and
A Cantalamessa, and
S Licenziati, and
L Peroni, and
E Prati, and
F Martinelli, and
A D Canaris, and
S Folghera, and
R Gorla, and
A Balsari
August 1992,
AIDS (London, England),
A Caruso, and
A Cantalamessa, and
S Licenziati, and
L Peroni, and
E Prati, and
F Martinelli, and
A D Canaris, and
S Folghera, and
R Gorla, and
A Balsari
February 1996,
Pediatric AIDS and HIV infection,
A Caruso, and
A Cantalamessa, and
S Licenziati, and
L Peroni, and
E Prati, and
F Martinelli, and
A D Canaris, and
S Folghera, and
R Gorla, and
A Balsari
August 2015,
Parasitology research,
A Caruso, and
A Cantalamessa, and
S Licenziati, and
L Peroni, and
E Prati, and
F Martinelli, and
A D Canaris, and
S Folghera, and
R Gorla, and
A Balsari
August 1997,
European journal of immunology,
