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Vinorelbine (Navelbine; Burroughs Wellcome Co, Research Triangle Park, NC; Pierre Fabre Médicament, Paris, France) is a novel semisynthetic vinca alkaloid with antitumor activity in non-small cell lung cancer. An oral preparation of this drug is under investigation and was tested in a multicenter phase II study in patients with stage IV measurable or evaluable non-small cell lung cancer. The initial vinorelbine dose was 100 mg/m2/wk (80 mg/m2/wk for patients with prior radiotherapy). Following an initial 37% incidence of grade 3 or 4 neutropenia, the dose was reduced by 40 mg/dose. Nausea, vomiting, diarrhea, and mucositis were other frequently observed toxicities. A preliminary analysis indicated a response rate of 14%, suggesting activity of this drug when administered orally.
E E Vokes, and
R Rosenberg, and
M Jahanzeb, and
J Craig, and
R Gralla, and
C Belani, and
S Jones, and
J Bigley, and
J Hohneker
April 1996,
Seminars in oncology,
E E Vokes, and
R Rosenberg, and
M Jahanzeb, and
J Craig, and
R Gralla, and
C Belani, and
S Jones, and
J Bigley, and
J Hohneker
April 1996,
Seminars in oncology,
E E Vokes, and
R Rosenberg, and
M Jahanzeb, and
J Craig, and
R Gralla, and
C Belani, and
S Jones, and
J Bigley, and
J Hohneker
October 1994,
Seminars in oncology,
E E Vokes, and
R Rosenberg, and
M Jahanzeb, and
J Craig, and
R Gralla, and
C Belani, and
S Jones, and
J Bigley, and
J Hohneker
October 1994,
Seminars in oncology,
E E Vokes, and
R Rosenberg, and
M Jahanzeb, and
J Craig, and
R Gralla, and
C Belani, and
S Jones, and
J Bigley, and
J Hohneker
April 1995,
Seminars in oncology,
E E Vokes, and
R Rosenberg, and
M Jahanzeb, and
J Craig, and
R Gralla, and
C Belani, and
S Jones, and
J Bigley, and
J Hohneker
April 1991,
American journal of clinical oncology,
E E Vokes, and
R Rosenberg, and
M Jahanzeb, and
J Craig, and
R Gralla, and
C Belani, and
S Jones, and
J Bigley, and
J Hohneker
October 1994,
Seminars in oncology,
E E Vokes, and
R Rosenberg, and
M Jahanzeb, and
J Craig, and
R Gralla, and
C Belani, and
S Jones, and
J Bigley, and
J Hohneker
January 1992,
European journal of cancer (Oxford, England : 1990),
E E Vokes, and
R Rosenberg, and
M Jahanzeb, and
J Craig, and
R Gralla, and
C Belani, and
S Jones, and
J Bigley, and
J Hohneker
March 2002,
Gan to kagaku ryoho. Cancer & chemotherapy,
E E Vokes, and
R Rosenberg, and
M Jahanzeb, and
J Craig, and
R Gralla, and
C Belani, and
S Jones, and
J Bigley, and
J Hohneker
April 1996,
Seminars in oncology,
