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Diabetic neuropathy typically presents as an insidious symmetrical distal degenerative disease of peripheral nerves. A failure of neurotrophic factors to regulate neuronal phenotype might be expected to result in such a clinical picture. Experimentally, diabetic rats show reduced expression of target-derived nerve growth factor as well as reduced expression of neuronal genes that are responsive to nerve growth factor. The latter is corrected by administration of exogenous nerve growth factor. Thus, deficient neurotrophic support might contribute to the pathogenesis of diabetic neuropathy, and any successful treatment might include exogenous neurotrophins or other strategies to correct their deficiency of action.
W J Brewster, and
P Fernyhough, and
L T Diemel, and
L Mohiuddin, and
D R Tomlinson
June 1998,
Revista de neurologia,
W J Brewster, and
P Fernyhough, and
L T Diemel, and
L Mohiuddin, and
D R Tomlinson
October 1996,
Lancet (London, England),
W J Brewster, and
P Fernyhough, and
L T Diemel, and
L Mohiuddin, and
D R Tomlinson
January 2003,
Experimental diabesity research,
W J Brewster, and
P Fernyhough, and
L T Diemel, and
L Mohiuddin, and
D R Tomlinson
November 1998,
Lancet (London, England),
W J Brewster, and
P Fernyhough, and
L T Diemel, and
L Mohiuddin, and
D R Tomlinson
January 1995,
Trends in neurosciences,
W J Brewster, and
P Fernyhough, and
L T Diemel, and
L Mohiuddin, and
D R Tomlinson
January 1995,
Trends in neurosciences,
W J Brewster, and
P Fernyhough, and
L T Diemel, and
L Mohiuddin, and
D R Tomlinson
January 1988,
Neurobiology of aging,
W J Brewster, and
P Fernyhough, and
L T Diemel, and
L Mohiuddin, and
D R Tomlinson
January 1999,
European neurology,
W J Brewster, and
P Fernyhough, and
L T Diemel, and
L Mohiuddin, and
D R Tomlinson
June 1996,
Seminars in neurology,
W J Brewster, and
P Fernyhough, and
L T Diemel, and
L Mohiuddin, and
D R Tomlinson
August 2018,
Medical science monitor : international medical journal of experimental and clinical research,
