-transparent.png){kind=logo}
A patient with a demyelinating sensory motor polyneuropathy secondary to IgM paraproteinaemia is reported. The paraprotein binds to the gangliosides GD1b, GT1b, GQ1b and GD3, all of which contain disialosyl groups with the sequence NeuAc alpha 2-8NeuAc alpha 2-3Gal. The paraprotein also acts as a cold agglutinin recognising the sialic-acid-dependent Pr1d antigenic determinant of the red cell membrane glycophorins. In this and in similar cases that have been reported, the coexistence of anti-Pr cold agglutinins and peripheral neuropathy suggest that they might be the causative agents of the disease.
Related Publications
B Herron, and
H J Willison, and
J Veitch, and
D Roelcke, and
L S Illis, and
F E Boulton
November 1993,
Journal of neurology, neurosurgery, and psychiatry,
B Herron, and
H J Willison, and
J Veitch, and
D Roelcke, and
L S Illis, and
F E Boulton
February 1980,
Revue francaise de transfusion et immuno-hematologie,
B Herron, and
H J Willison, and
J Veitch, and
D Roelcke, and
L S Illis, and
F E Boulton
January 1976,
Vox sanguinis,
B Herron, and
H J Willison, and
J Veitch, and
D Roelcke, and
L S Illis, and
F E Boulton
January 1975,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
B Herron, and
H J Willison, and
J Veitch, and
D Roelcke, and
L S Illis, and
F E Boulton
April 1986,
Journal of neuroimmunology,
B Herron, and
H J Willison, and
J Veitch, and
D Roelcke, and
L S Illis, and
F E Boulton
January 1973,
Folia haematologica (Leipzig, Germany : 1928),
B Herron, and
H J Willison, and
J Veitch, and
D Roelcke, and
L S Illis, and
F E Boulton
August 2001,
Deutsche medizinische Wochenschrift (1946),
B Herron, and
H J Willison, and
J Veitch, and
D Roelcke, and
L S Illis, and
F E Boulton
December 1987,
Annals of neurology,
B Herron, and
H J Willison, and
J Veitch, and
D Roelcke, and
L S Illis, and
F E Boulton
August 1992,
Muscle & nerve,
B Herron, and
H J Willison, and
J Veitch, and
D Roelcke, and
L S Illis, and
F E Boulton
August 2000,
Clinical reviews in allergy & immunology,
