-transparent.png){kind=logo}
In an attempt to define the effects of recombinant human erythropoietin (rEPO) on DNA synthesis in hematopoietic organs, we investigated DNA-synthesizing enzyme activities, i.e., thymidylate synthetase and thymidine kinase activities, and bromodeoxyuridine-immunohistochemistry during the recovery phase of hematopoietic cells in bone marrow and spleen after the hypoplastic period induced by cyclophosphamide (Cy) treatment in rats. Treatment with rEPO increased enzyme activities and cell number of erythroid series in bone marrow cells; it also increased organ weight and S-phase cells in the spleen, followed by an augmentation of the number of erythrocytes and a rise in the hemoglobin and hematocrit levels in peripheral blood with or without Cy treatment.
T Nakayama, and
H Kudo, and
S Suzuki, and
M Suenaga, and
S Sakamoto
August 1994,
Pediatric nephrology (Berlin, Germany),
T Nakayama, and
H Kudo, and
S Suzuki, and
M Suenaga, and
S Sakamoto
January 1992,
International journal of cell cloning,
T Nakayama, and
H Kudo, and
S Suzuki, and
M Suenaga, and
S Sakamoto
September 1988,
Blood,
T Nakayama, and
H Kudo, and
S Suzuki, and
M Suenaga, and
S Sakamoto
June 1989,
Blood,
T Nakayama, and
H Kudo, and
S Suzuki, and
M Suenaga, and
S Sakamoto
January 1993,
Haematologica,
T Nakayama, and
H Kudo, and
S Suzuki, and
M Suenaga, and
S Sakamoto
July 1989,
International journal of cell cloning,
T Nakayama, and
H Kudo, and
S Suzuki, and
M Suenaga, and
S Sakamoto
October 1990,
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
T Nakayama, and
H Kudo, and
S Suzuki, and
M Suenaga, and
S Sakamoto
May 2014,
Iranian Red Crescent medical journal,
T Nakayama, and
H Kudo, and
S Suzuki, and
M Suenaga, and
S Sakamoto
January 1999,
Nephron,
T Nakayama, and
H Kudo, and
S Suzuki, and
M Suenaga, and
S Sakamoto
November 2005,
European journal of clinical investigation,
