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We report here a family of patients with coexistent hereditary spherocytosis and alpha-thalassaemia. The different clinical presentations of the family members were affected by the severity of the alpha-thalassaemia. The haemolytic effect of hereditary spherocytosis was modulated by the increased osmotic resistance of thalassaemia in the patients with both disorders. Coexistence of haemoglobin H disease and hereditary spherocytosis resulted in an asymptomatic state. In contrast, coexistence of alpha-thalassaemia trait and hereditary spherocytosis was still haemolytic. The different shapes of the osmotic curves in the family members correlated with the severity of their symptoms.
C K Li, and
M H Ng, and
K L Cheung, and
T K Lam, and
M M Shing
August 1991,
Australian and New Zealand journal of medicine,
C K Li, and
M H Ng, and
K L Cheung, and
T K Lam, and
M M Shing
January 1968,
Acta haematologica,
C K Li, and
M H Ng, and
K L Cheung, and
T K Lam, and
M M Shing
December 1960,
British medical journal,
C K Li, and
M H Ng, and
K L Cheung, and
T K Lam, and
M M Shing
September 2001,
European journal of haematology,
C K Li, and
M H Ng, and
K L Cheung, and
T K Lam, and
M M Shing
February 1963,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
C K Li, and
M H Ng, and
K L Cheung, and
T K Lam, and
M M Shing
August 1965,
Archives of internal medicine,
C K Li, and
M H Ng, and
K L Cheung, and
T K Lam, and
M M Shing
June 1959,
Blood,
C K Li, and
M H Ng, and
K L Cheung, and
T K Lam, and
M M Shing
December 1968,
Journal of medical genetics,
C K Li, and
M H Ng, and
K L Cheung, and
T K Lam, and
M M Shing
February 2018,
Experimental and therapeutic medicine,
C K Li, and
M H Ng, and
K L Cheung, and
T K Lam, and
M M Shing
October 1988,
British journal of haematology,
