Biomaterial Database

The induction of specific protection against Actinobacillus pleuropneumoniae infection by specific DLE. 1993

J Snirc, and I Mikula, and J Pistl

Department of Microbiology and Immunology, University of Veterinary Medicine, Kosice, Slovakia.

Immunoprophylactic and immunotherapeutic effects of specific actinobacillus DLE (dialysable leukocyte extract) were studied in model pigs experimentally infected with Actinobacillus pleuropneumoniae. Specific DLE used for immunoprophylactic purposes was administered intramuscularly to pigs either in two doses in combination with one dose of actinobacillus vaccine (1st group) or in a single dose (2nd group). All animals of the two experimental groups survived the intranasal A. pleuropneumoniae challenge (2 x 2 ml 2-5 x 10(10) c.f.u.) while 3 of 5 animals of the control group died of haemorrhagic-necrotic fibrinous pneumonia. DLE administered to pigs for immunotherapeutic purposes was applied intravenously in two doses 1 and 5 h after the actinobacillus challenge (1st group), and in a single dose 5 h following the challenge (2nd group). All animals of the first group survived the challenge while 3 out of 5 animals of the second group and 4 out of 5 animals of the control group died during the experiment.

UI	MeSH Term	Description	Entries
D007167	Immunotherapy	Manipulation of the host's immune system in treatment of disease. It includes both active and passive immunization as well as immunosuppressive therapy to prevent graft rejection.	Immunotherapies
D005260	Female		Females
D000189	Actinobacillus Infections	Infections with bacteria of the genus ACTINOBACILLUS.	Infections, Actinobacillus,Actinobacillus Infection,Infection, Actinobacillus
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001428	Bacterial Vaccines	Suspensions of attenuated or killed bacteria administered for the prevention or treatment of infectious bacterial disease.	Bacterial Vaccine,Bacterin,Vaccine, Bacterial,Vaccines, Bacterial
D013552	Swine	Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).	Phacochoerus,Pigs,Suidae,Warthogs,Wart Hogs,Hog, Wart,Hogs, Wart,Wart Hog
D014165	Transfer Factor	Factor derived from leukocyte lysates of immune donors which can transfer both local and systemic cellular immunity to nonimmune recipients.	Dialyzable Leukocyte Extract,Extract, Dialyzable Leukocyte,Factor, Transfer,Leukocyte Extract, Dialyzable
D014611	Vaccination	Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis.	Immunization, Active,Active Immunization,Active Immunizations,Immunizations, Active,Vaccinations
D016977	Actinobacillus pleuropneumoniae	A species of gram-negative, facultatively anaerobic coccobacillus-shaped bacteria that has been isolated from pneumonic lesions and blood. It produces pneumonia with accompanying fibrinous pleuritis in swine.	Haemophilus pleuropneumoniae,Hemophilus pleuropneumoniae
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus