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Normal peritoneal macrophages from C3H/He mice could not lyse syngeneic MM46 tumor cells in co-operation with syngeneic antitumor antibody. Thus, normal macrophages could not effectively participate in the antibody-dependent macrophage-mediated tumor lysis in vitro. However, after activation in vivo by stimuli, such as lipopolysaccharide, BCG, or glycogen, macrophages could co-operate with antitumor antibody in cytolysis of target cells. In the cytolysis nonspecific activation of normal macrophages was an essential first step, followed by specific tumor lysis in the presence of an antitumor antibody (second step). Immune macrophages from resistant mice were apparently equal in functional state to activated macrophages. A two-step mechanism of tumor lysis in vitro in a syngeneic mammary tumor system is proposed.
M Yamazaki, and
H Shinoda, and
Y Suzuki, and
D Mizuno
January 1986,
Neoplasma,
M Yamazaki, and
H Shinoda, and
Y Suzuki, and
D Mizuno
September 1980,
Journal of the Reticuloendothelial Society,
M Yamazaki, and
H Shinoda, and
Y Suzuki, and
D Mizuno
September 1984,
Israel journal of medical sciences,
M Yamazaki, and
H Shinoda, and
Y Suzuki, and
D Mizuno
March 1984,
Journal of leukocyte biology,
M Yamazaki, and
H Shinoda, and
Y Suzuki, and
D Mizuno
January 1985,
Immunology today,
M Yamazaki, and
H Shinoda, and
Y Suzuki, and
D Mizuno
November 1978,
Journal of immunology (Baltimore, Md. : 1950),
M Yamazaki, and
H Shinoda, and
Y Suzuki, and
D Mizuno
January 1988,
Neoplasma,
M Yamazaki, and
H Shinoda, and
Y Suzuki, and
D Mizuno
June 1980,
FEBS letters,
M Yamazaki, and
H Shinoda, and
Y Suzuki, and
D Mizuno
February 1983,
Journal of the Reticuloendothelial Society,
M Yamazaki, and
H Shinoda, and
Y Suzuki, and
D Mizuno
November 1978,
Cancer treatment reports,
