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SP-6 was synthesized by solid phase method in 95% purity on HPLC. The data obtained from amino acid analysis and fast atom bombardment were in good agreement with theoretical values. Intravenous injection of SP-6 in rabbits at the dosage of 14.3 micrograms/kg. resulted in blood pressure reduction of 4.4 kPa, i.e. 34% (P < 0.001). When the concentration of SP-6 in Tyrode solution was 5.2 x 10(-4) mg/ml the contraction of rabbit duodenum longitudinal muscle increased by 105%. (P < 0.001). When the concentration was more than 1 x 10(-3) mg/ml, the contractile effect was restrained significantly. Dropping 30 microliters of SP-6 (1 x 10(-3) mg/ml) to toad intestinum tenue mesenteriale in situ, the mesentery arterioles were expanded by 30%.
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