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A girl with symptoms of von Willebrand's disease was found to have a slightly reduced or normal FVIII procoagulant activity, normal FVIII-related antigen (VIIIR:AG) and virtually absent von Willebrand's factor. The electrophoretic mobility of the VIIIR:AG in this patient's plasma and plasma fractions was increased and has been compared with that of two reported patients with FVIII variants. Her lysed platelets contained increased amounts of VIIIR:AG which had an increased anodal migration identical to her plasma VIIIR:AG. Experiments involving the selective absorption of a rabbit antiserum with the patient's plasma provide evidence that VIIIR:AG and von Willebrand's factor are immunologically distinct.
F G Hill, and
M C Chan, and
R M Hardisty
February 1984,
Thrombosis research,
F G Hill, and
M C Chan, and
R M Hardisty
January 1979,
Thrombosis research,
F G Hill, and
M C Chan, and
R M Hardisty
January 1981,
Thrombosis research,
F G Hill, and
M C Chan, and
R M Hardisty
May 1974,
Human pathology,
F G Hill, and
M C Chan, and
R M Hardisty
February 1981,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
F G Hill, and
M C Chan, and
R M Hardisty
November 1977,
British medical journal,
F G Hill, and
M C Chan, and
R M Hardisty
October 1974,
Lancet (London, England),
F G Hill, and
M C Chan, and
R M Hardisty
July 1982,
Blood,
F G Hill, and
M C Chan, and
R M Hardisty
August 1973,
Nature: New biology,
F G Hill, and
M C Chan, and
R M Hardisty
August 1982,
Blood,
